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When buying Tadalafil on the internet, make sure that you are asked to answer several questions in the form of a reliable health form and that a qualified doctor checks your order.

Important to know about tadalafil

  • Tadalafil widens some blood vessels. This allows the blood to flow better.
  • For erection problems (difficulty getting an erect penis), pulmonary arterial hypertension (increased blood pressure in the lungs), and urination problems due to an enlarged prostate.
  • Erection problems: after half to 1 hour, the penis becomes erect due to sexual stimulation. The effect disappears after a few hours.
  • Pulmonary arterial hypertension: from about 12 weeks the tightness decreases.
  • Urinary problems due to an oversized prostate: you will notice after 1 to 2 weeks whether it is working well enough.
  • Do not use tadalafil more than once a day, otherwise, you will have too many side effects.
  • Most common side effects: headache, abdominal pain, nausea, hot flashes, muscle aches, and nasal congestion. You may also become dizzy or have blurred vision. Notify your doctor if you suddenly see or hear less well.
  • People with cardiovascular disease (such as a heart cramp, after a heart attack or stroke) can get complaints again. Do you get chest pain? Immediately notify a doctor.
  • Are you pregnant? Or do you want to become pregnant? Ask your doctor or pharmacist if you can use this medicine.
  • Are you breastfeeding? Ask your doctor or pharmacist if you can use this medicine.

What does tadalafil do and what do I use it for?

Tadalafil dilates some blood vessels and promotes erection.

Doctors prescribe it for sexual disorders (erectile problems), pulmonary arterial hypertension, and an enlarged prostate.

Sexual Disorders

An erection occurs because the blood vessels in the penis widen during sexual stimulation. This allows the so-called erectile tissues in the penis to flow full of blood. The blood vessels that have to drain the blood are temporarily closed. This keeps the penis stiff during sexual stimulation.

Cause
In erectile dysfunction, the penis cannot become erect or cannot remain erect long enough during sexual stimulation. Causes for this can be:

  • age: erection ability gradually declines with age;
  • psychological causes such as anxiety, stress, or depression;
  • diseases such as diabetes, hormone diseases, cardiovascular diseases, prostate diseases;
  • certain medicines or excessive alcohol and drug use.

Effect
Blood vessel dilation is initiated by substances that are released into the penis during sexual stimulation. Tadalafil inhibits the breakdown of these vasodilators. They, therefore, remain longer and in larger quantities in the penis. As a result, the penis can become stiffer better and stays stiff for longer. Sexual stimulation is required for it to work.

The effect starts after about half an hour and reaches a maximum after about 2 hours.
Up to 36 hours after ingestion you will get an erection more easily if you are sexually stimulated.

Pulmonary Arterial Hypertension

Symptoms
Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the pulmonary vessels. This affects heart function. The blood is no longer pumped properly. You are short of breath, tired more easily, and may experience chest pain, fainting, and fluid in the legs.

Causes
PAH can be congenital or the result of another condition. For example, a congenital heart defect, pulmonary fibrosis or scleroderma. These conditions cause inflammation in blood vessels, kidneys, intestines or lungs, causing scar tissue. The walls of blood vessels, alveoli, and other organs become stiff and no longer work properly. The heart can no longer contract properly. As a result, the heart no longer pumps blood properly and heart failure occurs.

Treatment
PAH is a serious disease. In the past there was no treatment and a lung transplant was the only remedy. Now there are several drugs, including tadalafil.

How
it works Tadalafil widens the blood vessels. This lowers the blood pressure in the vessels of the lungs. These effects allow the heart to put less pressure on the blood flowing to the lungs. The heart then has to work less hard. Which reduces the symptoms of pulmonary arterial hypertension.

You will notice that you are less tired and short of breath from 12 weeks of use.

prostate enlargement

Men can have different types of urination complaints, such as no longer being able to urinate forcefully, often having to urinate small amounts, and suffering from dripping.

There are a number of possible causes, and sometimes there is a combination of causes.
One of the causes is inflammation or damage to the bladder or prostate. Furthermore, diseases, such as heart failure or diabetes, can cause urinary symptoms. Also, blockage in the intestines can put pressure on the bladder. In rare cases, urinary symptoms are caused by an enlargement of the prostate. Often the exact cause cannot be found.

Prostate
Enlarge The prostate is a gland that surrounds the urethra in men near the bladder. If the prostate is enlarged, it can press on the urethra. The drainage of the urine then runs less smoothly

Your prostate can enlarge from the age of 30, by the age of eighty 9 in 10 men have an enlarged prostate. So it is a normal aging phenomenon. Half of these men will eventually have urinary problems.

Treatment
Sometimes you can find out by keeping a “urine diary” whether there are causes for the urinary complaints. For example, drinking a lot in the evening can give you more urgency at night. Drinking too little can actually cause constipation, and therefore also cause urinary symptoms. Sufficient physical activity and pelvic floor exercises can relieve symptoms in some people.

Doctors prescribe medication if these precepts do not help. Usually, this is initially an alpha-blocker, because these drugs work fastest against the complaints. If that does not help enough, the doctor will prescribe other medicines, such as finasteride, dutasteride, or tadalafil.

Action
Tadalafil relaxes the muscles of the prostate and the exit of the bladder. This makes the urethra less narrow and allows the urine to flow better. However, the prostate remains the same size as before.

Tadalafil does not work equally well for everyone. If the medicine works for you, you can expect an improvement in the complaints after 1 to 2 weeks.

What are possible side effects?

In addition to the desired effect, this can cause drug side effects. The main side effects are listed below. Side effects are more common with pulmonary arterial hypertension (PAH) than with use as an erection agent or with prostate enlargement because the dose is higher with PAH. The frequencies below are those reported for use with PAH.

Uncommon (affects 10 to 30 in 100 people)

  • Nausea, abdominal pain, heartburn, vomiting. 
  • Headache, hot flashes, flushing. An occasional migraine.
  • Back pain, muscle pain, pain in arms and legs.
  • Cold, sore throat, stuffy nose, very rarely nosebleed.

Rare (affects 1 to 10 people in 100)

  • Dizziness, fainting. 
  • In women: bleeding longer during menstruation.

Very rare (affects less than 1 in 100 people)

  • Eye complaints, such as blurred vision, a blue-green haze before the eyes, double vision, swollen eyelids, painful red eyes, light sensitivity, and loss of visual field.
     
  • Excessive sweating.
  • Ringing in the ears, suddenly unable to hear well. 
  • Prolonged and sometimes painful erection, bleeding from the penis or blood in urine or semen. 
  • Heart cramps, palpitations, myocardial infarction, and stroke. 
  • Attack with muscle twitches and muscle cramps ( convulsions ). 
  • A sickle cell crisis in people with sickle cell disease. 
  • Hypersensitivity to tadalafil. 

Talk to your pharmacist or doctor if you are experiencing too many of these or any other side effects that worry you.

Explanation frequencies

Regular: affects more than 30 people in 100
Uncommon: affects 10 to 30 people in 100
Rare: affects 1 to 10 people in 100
Very rare: affects less than 1 person in 100

How do I use this medicine?

When?

  • Erectile dysfunction:
    You can take the tablet half an hour before sexual activity. You can also take it earlier because the effect of 1 tablet can last for 36 hours. If you expect to have sex twice a week, it is also possible to take tadalafil at a fixed time every day. Never use 1 dose twice a day.
    If you experience nausea or stomach upset, you can take the tablet with some food.
  • Pulmonary arterial hypertension (PAH) and prostate enlargement:
    You can take the drug at any time of the day. It is best to choose a fixed time, for example in the morning, so that you are less likely to forget a dose. If you experience nausea or stomach upset, you can take the tablet with some food.

How long?

  • Erectile dysfunction and prostate enlargement :
    If tadalafil works well for you, you can take it for as long as you need it.
  • Pulmonary arterial hypertension (PAH) :
    You can usually take this drug for several months or years. Over time, tadalafil may become ineffective as PAH disease may worsen over time. Consult with your doctor if your symptoms return.

What should I do if I forget a dose?

Pulmonary arterial hypertension and prostate enlargement :

You are taking this medicine once a day :
Have you forgotten a dose and are less than 8 hours late? Then still take this dose. Are you more than 8 hours late? Skip the dose you missed. Do not take a double dose.

Can I drive, drink alcohol, and eat or drink anything with this drug?

drive a car?
This drug may cause dizziness and blurred vision. Do not participate in traffic as long as it affects you.

drinking alcohol?
Alcohol widens blood vessels, just like this drug. This can make you more prone to dizziness. Try drinking alcohol in moderation first. You can then estimate for yourself whether this will bother you a lot. Usually a glass of wine a few times a week is not a problem.
Drinking a lot of alcohol also reduces the ability to get an erection. Are you using this drug as an erection agent? Do not use too much alcohol in combination with this medicine.

eat everything?
There are no restrictions on this drug.

Can I take Tadalafil with other medicines?

This drug has interactions with other medications. The text below only lists the active ingredients of these medicines, not the brand names. You can find out whether your medicine contains one of these active substances in your package leaflet under the heading ‘composition’.

The drugs with which the main interactions occur are the following.

  • Nitrate vasodilators, such as nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, and nicorandil. Taking these medicines at the same time as tadalafil can cause sudden and prolonged low blood pressure. Please note: so-called ‘poppers’, sometimes used for sexual activity, also contain nitrates. Contact your doctor if you have chest pain.
    If you are taking tadalafil for erectile dysfunction:
    • Have you taken any of these medications and now want to take tadalafil? Wait at least 24 hours before using it.
    • Have you taken tadalafil and now want to take one of these drugs? Wait at least 48 hours before using this.
      Are you taking tadalafil for pulmonary hypertension (increased blood pressure in the lungs) or an enlarged prostate? Talk to your doctor. He may be prescribed a different drug.
  • Other medicines for enlarged prostate are alfuzosin, doxazosin, and terazosin. The combination may temporarily lower your blood pressure. You notice this in dizziness. This will pass by itself. Do not stand suddenly if you are dizzy.
  • The antibiotics are clarithromycin and erythromycin, the antifungals itraconazole and voriconazole, and the drug for Cushing’s disease is ketoconazole. The amount of tadalafil in the blood can rise due to these drugs. This makes the side effects stronger. Consult your doctor if you have been prescribed this combination.
  • Some medicines for HIV and hepatitis C . Ask your pharmacist which medicines this concerns.

Not sure if any of the above trade-offs are of interest to you? Then contact your pharmacist or doctor.

Can I use this medicine if I am pregnant, planning to become, or breastfeeding?

Pregnancy
Talk to your doctor. Too little is known about the use of this drug during pregnancy. Weigh the seriousness of your illness against the possible harm to the child together with your doctor.

Breast
-feeding If you want to breastfeed, talk to your doctor. It is not known whether this drug passes into breast milk or if it will harm the baby.

Can I use this medicine if my kidneys or liver are not working properly?

Kidneys

Are your kidneys working less well? Then consult your pharmacist. The dose of your medicine may need to be adjusted. Or that another drug is more suitable.

Do your do dialysis? Then consult your pharmacist. You may need to adjust your medication use. For example:

  • a different dose;
  • another day or time to take your medicine;
  • another drug.

Liver

It is not known whether people with liver cirrhosis can safely use this drug.

Can I just stop taking this medicine?

If you occasionally use this drug for erectile dysfunction, you can stop taking it without further ado.

If you take this medication every day, talk to your doctor. In that case, it is usually better to gradually reduce the dose. Then you have less chance that the original complaints will come back too violently at once.

Do I need a prescription?

Tadalafil has been on the market internationally since 2002. It is available by prescription in tablets under the brand names Cialis, Adcirca and Talmanco and as the unbranded Tadalafil.

Cialis is used for erection problems and an enlarged prostate, and Adcirca is only used for pulmonary arterial hypertension (PAH).

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