The active substance in requip, called ropinirole, relieves the symptoms associated with moderate to severe forms of restless leg syndrome , including suppressing the urge to move the lower limbs and others.
What is Requip (Ropinirole)
The drug Requip is manufactured by the Sun Pharmaceutical Industries Ltd. Its active substance , Ropinirole , is a dopamine antagonist , used to relieve the symptoms of restless legs syndrome in its moderate to severe forms. These symptoms are characterized by unpleasant sensations, such as itching, tingling, electric shocks, or even pain in the legs or other limbs. By reducing these symptoms, the desire to move the limbs is in turn reduced. In particular, this reduces muscle activity during sleep.
- Dopamine agonist
- Treats restless legs syndrome
- Branded version of Ropinirole
Restless Leg Syndrome (RLS)
The restless legs syndrome , also known under the name of disease Willis-Ekbom , is a disease that affects the central nervous system. It causes an overwhelming urge to move the legs, although it can affect the arms as well.
Symptoms of restless leg syndrome include the overwhelming urge to move , especially the legs . It can also cause unpleasant and uncomfortable tingling sensations in the legs, ankles, calves and thighs. These symptoms can get worse at night and interfere with sleep . The pathology is associated with uncontrollable movements of the limbs, medically known as periodic limb movements during sleep (PLMS) . Symptoms can range from moderate to severe and can appear at different times of the day, and the duration more or less variable.
Causes of RLS
The cause of this disease is not clearly identified to date , even if the hereditary factor is privileged.
Some scientists believe the cause of restless leg syndrome may be linked to a chemical called dopamine, a hormone produced naturally in the brain. This is because dopamine plays a role in the movement of muscles. It is thought to have something to do with the involuntary twitching associated with restless leg syndrome.
In more rare cases, restless legs syndrome can be a sign of an underlying health problem , such as iron deficiency or kidney disease . In addition, one in five women who enter the third trimester of their pregnancy have symptoms of restless leg syndrome – although they usually go away after birth.
“ The first step in management […] is to identify and treat a root cause of secondary RLS, such as iron deficiency, and to identify drugs that can cause or worsen disease. ” 
No cure currently exists for restless leg syndrome (RLS).
Some lifestyle changes can help, including adopting good sleep hygiene, stopping smoking, and regular physical activity.
In the more severe cases of restless leg syndrome, medical treatment may be prescribed to relieve the symptoms of RLS. The drugs help regulate dopamine levels or, in cases where it is caused by iron deficiency, iron supplements. Anyone can suffer from restless leg syndrome, although it is more often seen in women and people of middle age.
“ The initiation of pharmacological treatment is limited to patients with strict diagnostic criteria, is assessed on an individual basis and dictated by the clinical implications of RLS. ”
In other words, restless legs syndrome should only be treated with medication if the above lifestyle changes have not worked, or in severe forms. Failure to treat RLS does not change the course of the disease. For example, the drug Requip does not accelerate or slow the deterioration of the disease compared to no drug. It should be noted that Requip generally helps people with RLS, but the improvement is relatively short-lived. Requip should not be taken for more than 6 months. Taking longer will bring little benefit, and can sometimes even make the disease worse.
If you would like to renew your Requip prescription, you can do so using our online service. Simply complete our medical questionnaire to have your symptoms assessed by a member of our qualified medical team. Subject to approval, we will ship your order in discreet, tracked packaging.
Requip is available in different strengths: 0.25 mg, 0.50 mg 1 mg and 2 mg .
The dosage and frequency of taking Requip must be adapted according to each individual according to their needs, the effectiveness of the treatment and their tolerance to the drug.
Requip should preferably be taken with a meal to improve gastrointestinal tolerance, and at best 3 hours before bedtime.
Requip 0.25 mg
The recommended starting dose of Requip is 0.25 mg. This is the dose prescribed for first-line treatment when starting treatment.
If this dose is well tolerated, an increase in the dosage may be considered if necessary.
Requip 0.50 mg
After starting the drug Requip 0.25 mg, the strength of 0.50 mg may be prescribed if the lower dose has not produced the desired results .
Requip 2 mg
If the dosage of Requip 0.50 mg still does not prove to be effective, the dose may be increased up to 2 mg to achieve an optimal therapeutic response. The increase in dosage should be done gradually in order to avoid the appearance of side effects.
The taking of the drug Requip should be evaluated after 3 months of treatment. The dose and the need for continued treatment should be re-evaluated. If treatment is interrupted for several days, the dosing schedule should be restarted starting with the initial dose.
It is important that you always take Requip as prescribed by your doctor. If you are not sure, talk to your doctor or pharmacist.
- Take the drug Requip according to the medical instructions;
- The dosage may vary depending on the severity of the symptoms;
- The initial treatment is with the lowest dose of Requip 0.25 mg;
- Your doctor must supervise your treatment;
- Your dose may be increased if the symptoms do not improve;
- Take the tablet whole with water;
- Taking Adartrel with meals helps reduce the risk of nausea;
- To be taken every day at a fixed time as far as possible;
- If you forget to take a dose, skip it and take a new tablet the next day at the usual time;
- If you miss several doses, talk to your doctor;
- Do not stop taking this treatment without talking to your doctor first.
For more detailed advice on how to take Requip, read the package leaflet that comes with the medicine pack.
Requip and side effects
Like all medicines, Requip can cause some side effects. Most people will not be affected, but it is important to know what side effects you might experience. If in doubt, please consult a doctor.
Feelings of nervousness, fainting, drowsiness, fatigue, dizziness, stomach pain, increased severity of RLS symptoms, swelling of the legs, feet and / or hands.
Confusion, hallucinations, feeling weak or dizzy – especially when standing.
Changes in liver function, feeling drowsy or tired during the day, falling asleep suddenly, sometimes without feeling tired beforehand.
Allergic reaction, symptoms of which may include redness, rash, itching, wheezing, difficulty breathing, coughing, inflammation of the mouth, lips, throat and tongue, hives, other psychotic conditions associated with hallucinations, such as extreme confusion, delusions or paranoia, aggression, drug dependence, called dopamine dysregulation syndrome, mental health conditions such as as depression, anxiety, listlessness, low energy, sweating, and withdrawal symptoms after stopping treatment.
In addition, some people, the frequency of which is unknown, may experience the inability not to act impulsively. It can take many forms, including harming yourself or others, gambling excessively despite the financial consequences, altering your sexual desire, uncontrolled spending and overeating.
It is very important that you tell your doctor if you notice any of the serious side effects listed above.
You should tell your prescriber about any medicine you have taken, or are currently taking, so that they can assess whether Adartrel is right for you. When certain drugs interact, they can interfere with the effectiveness of other treatments or cause certain side effects.
In particular, Adartrel may interact with the following substances: fluvoxamine, an antidepressant, any medication for mental health problems, a hormone replacement medication, the antibiotics ciprofloxacin and enoxacin, any medication that blocks dopamine in the brain, antagonists of vitamin K and warfarin.
Actions to be taken
Diseases to watch out for
You should tell your prescriber if you have any concomitant illness. It is especially important to mention if you have, or have ever had, liver disease, a serious heart problem, mental health problems, unusual or impulsive behavior, an addictive nature or if you are intolerant to sugar or lactose. .
Pregnancy and breast feeding
Requip is not recommended if you are pregnant or breastfeeding. If you are already taking Requip and become pregnant, you should talk to your doctor immediately.
Driving and using machines
This medicine can cause some side effects such as drowsiness, fatigue and hallucinations. In very rare cases, it can cause you to fall asleep unexpectedly. If you get any of these side effects, you should not drive or use machinery. If in doubt, talk to your doctor or pharmacist.
Food, drinks and alcohol
Taking this medicine with food may reduce the risk of nausea. You should not drink alcohol while taking this treatment.
Adartrel contains small traces of lactose. If you have lactose intolerance, do not take this medicine.
This medicine can only be obtained with a prescription from a doctor or a prescriber.
Reimbursement of Requip
Requip is not subject to social security reimbursement for moderate and severe forms of restless legs syndrome.
On the other hand, Adartrel is reimbursed up to 65% in the very severe forms of RLS, because the treatment has the most marked benefits in this context. By very severe form we mean:
- Patients with a significant negative impact on daily, family, social and / or professional life, and / or a significant sleep disturbance, an IRLS score> or = 31;
- An initial medical prescription from a neurologist or doctor specializing in the treatment of sleep disorders.
Conservation of Requip
Away from children, at a temperature not exceeding 25 ° C , in a cool and dry environment.
Requip and alcohol
You should refrain from drinking alcohol while you are taking the medicine Requip.
Requip and conduct
If you experience certain side effects from this medicine, such as fatigue and drowsiness, you should not drive. Your doctor may adjust the dose of the medicine to try to reduce its side effects.
Requip and pregnancy
You should tell your doctor or prescriber if you are pregnant, breastfeeding or planning to conceive. Requip is generally not prescribed for women who are pregnant or breastfeeding.
Requip and allergies
Do not take this medicine if you are allergic to its active substance, Ropinirole. The other ingredients can be lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.
- Requip 0.25 mg : hypromellose, macrogol 400, titanium dioxide (E171), polysorbate 80 (E433)
- Requip 0.5 mg : hypromellose, macrogol 400, titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172), indigo carmine aluminum lake (E132)
- Requip 2 mg : hypromellose, macrogol 400, titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172)
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