Buy Priligy Online for Premature Ejaculation

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Buy Priligy Online

When buying Priligy on the internet, make sure that you are asked to answer several questions in the form of a reliable health form and that your order is checked by a qualified doctor.

What is Priligy?

Priligy is the only oral premature ejaculation preventive drug developed for the first time in the world. Dapoxetine, the active ingredient, is classified as SSRI (selective serotonin reuptake inhibitor) and has the effect of inhibiting the reuptake of serotonin at nerve endings.

It is said that one of the causes of premature ejaculation is related to the chemical imbalance of serotonin, and normalizing the chemical activity in the brain, it improves the state of hypersensitivity to sexual stimulation and has an effect on premature ejaculation. By taking it, the time from insertion into the vagina of a woman to ejaculation (intra-vaginal ejaculatory latency time (IELT)) is extended, and ejaculation can be controlled well.

History of Priligy

Dapoxetine was developed by Janssen Sirag, Johnson & Johnson’s pharmaceutical division, and in 2004 a new drug application was submitted to the US Food and Drug Administration for its effectiveness in premature ejaculation.

In response, the US Food and Drug Administration disapproved of dapoxetine in October 2005 and requested additional clinical efficacy and safety data.

Three additional efficacy/safety studies were conducted, safety and efficacy data were submitted to health authorities, and dapoxetine was reported in Sweden, Finland, Austria, Portugal, Germany, Italy, Spain, Mexico, South Korea, and New Zealand 2010. Approved in the year.

Since then, it has been approved in other European countries and Australia, and since 2012, Menarini has acquired the right to commercialize dapoxetine in Europe, most of Asia, Africa, Latin America, and the Middle East, and is expanding its sales channels.

Currently, it has been approved in more than 50 countries and is sold and distributed in more than 30 countries. Unfortunately, it has not been approved in the United States, Canada, and Japan, and is currently being developed by Flux, which has transferred the product rights of Priligy by concluding a contract with Janssen Sirag.

Priligy was developed by Janssen Sirag and sold by Menarini

Dapoxetine, the active ingredient in Priligy, was originally developed as an antidepressant. However, SSRIs containing dapoxetine have been shown to be effective against premature ejaculation, and based on the current situation of off-label use, Johnson & Johnson’s pharmaceutical division Janssen Sirag has been developing it as a premature ejaculation preventive drug.

Janssen Sirag, assuming that premature leakage is caused by a chemical imbalance of serotonin that affects neurotransmission (chemical activity in the brain), has a very strong serotonin reuptake inhibitory effect on dapoxetine. Focusing on the concentration of serotonin in the brain and the transmission pathways of neurotransmitters caused by it, we created Priligy as a premature leakage preventive drug. Sales are handled by Menalini in many countries.

shape

The shape is a tablet, a film-coated tablet. There are two types of tablets, 30 mg tablets and 60 mg tablets, each containing dapoxetine hydrochloride, which is equivalent to dapoxetine 30 mg or 60 mg.

The 30 mg tablet is a circle with a diameter of 6.5 mm, a light gray convex shape, an inverted triangle drawn on one side, and “30” engraved on the inside. The 60 mg tablet is a circle with a diameter of about 8 mm, has a gray convex shape, an inverted triangle is drawn on one side, and “60” is engraved on the inside, and the excipient lactose 30 mg tablet is 45.88 mg. , 60 mg tablets contain 91.75 mg.

As excipients, lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, and magnesium stearate are used in the core part, and lactose monohydrate, hypromellose, and titanium dioxide (E171) are used in the coated part. , Triacetin, Iron Oxide Black (E172), Iron Oxide Yellow (E172).

There are multiple packaging formats, with one, two, three, or six film-coated tablets on PVC (polyvinyl chloride) sheets, polyethylene (PE) sheets, and polyvinylidene chloride (PVDC) sheets, or ALU blister sheets. ____ is inside. Not all forms exist in the market in each country.

Pharmacology

Dapoxetine is a powerful SSRI whose structure resembles fluoxetine. In 2005, in an equilibrium radioligand binding study using human cells, dapoxetine bound to serotonin (5-HT), norepinephrine (NE), and dopamine (DA) reuptake transporters, and NE <5-HT>. It was shown to inhibit uptake in the order of> DA, and in 2012 it was found that dapoxetine strongly blocks potassium potential-dependent channels involved in the regulation of neurotransmitter release.

It is said that serotonin concentration is involved in the onset of premature ejaculation, and it is said to be caused by action potential imbalance in the brain, but the direct factors range from physical factors to psychological factors, and dapoxetine was used in 1993-2012. During this period, two Phase 2 clinical trials and five Phase 3 trials have been conducted, demonstrating the effect on premature ejaculation.

In the phase 2 study, the dose was examined and up to 100 mg of dapoxetine was tolerated, but the optimal dose was 30 mg to 60 mg because of side effects. In Phase 3 trials, dapoxetine 30 and 60 mg contributed to prolonging IELT, improving patient-reported outcomes (PRO), reducing ejaculation-related stress, reducing insertion stress, and improving sexual satisfaction compared to placebo. It has been statistically shown to do.

The active ingredient that Janssen Sirag focused on

Janssen Silag focused on the chemical imbalance of serotonin, which affects neurotransmission (chemical activity in the brain) as a cause of premature ejaculation, and used dapoxetine, which has a very strong serotonin reuptake inhibitory effect, as an active ingredient. Started developing medicine.

Premature ejaculation has a low amount of serotonin secreted in the brain, and noradrenaline, a neurotransmitter related to ejaculation, works significantly, and ejaculation occurs with a slight stimulus. The amount of this noradrenaline increases due to stress such as anxiety and tension, and when noradrenaline increases, it becomes easier to ejaculate.

On the other hand, serotonin is also a neurotransmitter involved in ejaculation, but it also suppresses the action of noradrenaline and at the same time the action of dopamine, which has the effect of amplifying pleasure. Therefore, taking dapoxetine increases the concentration of serotonin in the brain by inhibiting the reabsorption of serotonin, suppressing the secretion of noradrenaline suppressing hyperexcitability in the brain, and prolonging the ejaculation time, resulting in premature ejaculation. Shows the effect.

Its strong action on serotonin is known to act specifically on the ejaculatory center, and its high effect on premature ejaculation has been confirmed.

How to use Priligy

Priligy is valid for 3 years and you should not take Priligy if it has expired as stated on the package. Also, if the packaging is torn or if there are signs of tampering when you receive the drug, never use it, and immediately contact the prescribing and shipping sources before returning it.

If you are satisfied with the packaging and expiration date, start taking Priligy. When not taking it, keep it sealed and do not leave it on the windowsill or in a car. Do not store near a bathroom or sink as it is best stored in a cool, dry place below 25 ° C.

Because heat and humidity can change the composition of the medicine, it can change the efficacy. Also, don’t forget to keep it out of the reach of children. A cupboard with a key 1.5 meters above the ground is the best place to store it.

When disposing of Priligy due to expiration, etc., do not flush it with water or dispose of it as household waste, and there are rules for disposing of drugs in each region, so please check the rules in your area. .. If you don’t understand the rules, ask your pharmacist at your pharmacy.

Dapoxetine, the active ingredient of Priligy

The active ingredient in Priligy is dapoxetine, which is classified as a selective serotonin reuptake inhibitor (SSRI). Dapoxetine is thought to target the neurotransmission of serotonin (chemical activity in the brain) and restore the serotonin imbalance in the body to its normal state.

Serotonin is a chemical present in the nervous system that is thought to be involved in the ejaculation process, and dapoxetine premature ejaculation by increasing levels of serotonin in the nervous system may prolong the time to ejaculation. Shows the effect. Taking the drug can be expected to improve ejaculation control ability, prolong the time to ejaculation, improve sexual satisfaction, realize that premature ejaculation has improved, and reduce the level of pain associated with premature ejaculation.

Effect of delaying ejaculation

There are two autonomic nerves that are deeply involved in erection and ejaculation: the sympathetic nerve and the parasympathetic nerve. It is the parasympathetic nerves that work significantly during erection, dilating blood vessels in the penis and sending blood to the corpus cavernosum into the penis to promote erection, and conversely, the sympathetic nerves work significantly during ejaculation.

Premature leakage is thought to be more sympathetic than normal, and the significant sympathetic state is caused by hypersecretion of the intracerebral neurotransmitter noradrenaline and further noradrenaline. Will promote the secretion of.

It is known that noradrenaline is easily secreted due to tension, anxiety, anxiety, stress, etc., and if you feel stress in the state of premature ejaculation, the secretion of noradrenaline will be repeated. Dapoxetine, the active ingredient in Priligy, is an SSRI that suppresses the reuptake of serotonin at nerve endings.

Serotonin is released from synapses between neurons and is reuptake by the serotonin transporter present in the nerve cell membrane. Dapoxetine inhibits the reuptake, and the action of serotonin in the postsynaptic fissure is exerted. Increases and, as a result, prolong the time it takes to ejaculate.

Mechanism of action of dapoxetine

Ejaculation involves noradrenaline and serotonin, which are neurotransmitters present in the brain, and it is said that serotonin is generally deficient, but premature ejaculation causes excessive secretion of noradrenaline. Or it is deficient in serotonin and has a relative excess of noradrenaline.

Dapoxetine, the active ingredient of Priligy, is SSRI, which increases the concentration of serotonin in the brain by inhibiting the reuptake of serotonin at nerve endings, and serotonin acts to suppress the action of noradrenaline, so the concentration of serotonin is high. When it increases, the function of noradrenaline weakens.

Noradrenaline creates a sympathetic predominant state, and abnormal arousal creates a hypersensitivity state to sexual stimulation of the penis. When serotonin levels increase and noradrenaline levels become normal, premature ejaculation is prevented by subsided arousal and near-normal penile sexual stimulation. Compared to other SSRIs, dapoxetine has the function of increasing the concentration of serotonin in the ejaculatory center in the brain, where sexual arousal is transmitted during ejaculation and is highly effective against premature ejaculation.

Selective Serotonin Inhibitor (SSRI)

Selective serotonin inhibitors (SSRIs) are antidepressants that block the reabsorption of serotonin at synapses. Serotonin is a neurotransmitter in the brain that is released from presynaptic neurons and binds to serotonin receptors in postsynaptic neurons.

Serotonin present in the synaptic cleft is reuptake by the serotonin transporter. SSRIs selectively bind to serotonin transporters at synapses that release serotonin and suppress serotonin reuptake. As a result, high levels of serotonin in the brain will be maintained.

There are various physiological functions related to serotonin in the brain, but typical ones are involved in pathological conditions such as mood disorders and schizophrenia and have the effect of stabilizing emotional information by dopamine and noradrenaline. , Is responsible for physiological functions such as neuroendocrine and sleep.

Dapoxetine, the active ingredient of Priligy, is also classified as SSRI, and by increasing the concentration of serotonin in the brain, it has the effect of suppressing the hypersensitivity of the penis to sexual stimulation caused by the hyper sympathetic nerve hyperactivity caused by noradrenaline. increase.

Priligy effect

Priligy is a drug used to treat men aged 18 to 64 years with premature ejaculation. It is prescribed for men who are out of control, such as ejaculation within 1 minute of vaginal insertion due to slight sexual stimulation, which causes stress and relationships with partners.

Many clinical trials have been conducted to date, and the data summarizes that taking 30 mg or 60 mg for each sexual activity for 12 or 24 weeks improves the symptoms of premature ejaculation compared to not taking it. As a result of the questionnaire about the degree, the result showed that the ejaculation control ability was improved and the worries about premature ejaculation were improved.

efficacy

Priligy is indicated for the treatment of premature ejaculation in adult males aged 18-64 years. Priligy is indicated for patients who meet all of the following five criteria:

  • IELT within 1 minute
  • Those who continue to ejaculate or have relapsed due to slight sexual stimulation at an unintentional speed, such as before vaginal insertion or immediately after vaginal insertion
  • Those who are feeling stressed as a result of premature ejaculation and are having trouble with their relationship with their partner
  • Those who have difficulty controlling ejaculation
  • Those with a history of premature ejaculation in most of the sexual activity in the last 6 months

Dapoxetine is a powerful selective serotonin reuptake inhibitor (SSRI). Human ejaculation is primarily mediated by the sympathetic nervous system, and the ejaculatory pathway begins at the spinal reflex center and is affected by numerous nerve nuclei in the brain.

Dapoxetine inhibits the reuptake of serotonin in nerve cells and also acts on receptors present at nerve endings and synapses to increase the concentration of serotonin in the brain. As a result, it suppresses the excessive secretion of the neurotransmitter noradrenaline, suppresses the hyperactive state of the sympathetic nerve, and suppresses the sympathetic nerve, so that the hypersensitivity state of the penis to sexual stimulation can be suppressed, and premature ejaculation can be suppressed. Shows the effect.

effect

As a result of taking a questionnaire on the degree of improvement of premature ejaculation symptoms (mild, moderate, marked improvement) when taking Priligy, an extension of IELT, improvement of ejaculation control ability (significant improvement, moderate improvement, mild improvement, Immutable, mild deterioration, moderate deterioration, self-evaluation with marked deterioration), improvement of premature ejaculation worries (significant improvement, moderate improvement, mild improvement, unchanged, mild deterioration, moderate deterioration, self-assessment with marked deterioration) It turned out that it is effective for evaluation).

IELT has been shown to have a prolonging effect from the first dose, and the degree of improvement in premature ejaculation symptoms has been confirmed from the first dose. In addition, it is known that the improvement rate of these effects increases in a dose-dependent manner, and a higher effect can be expected with 60 mg administration than with 30 mg administration. However, please be sure to judge the dose by looking at the degree of effect on yourself.

It has been reported that if you continue to take it every time you have sexual activity, after 24 weeks, if you take 30 mg, IELT will be 3.7 times and the improvement rate will be less than 60%, and if you take 60 mg, IELT will be 4.3 times and the improvement rate will be more than 70%. I am.

Regarding the improvement of ejaculation control ability and premature ejaculation trouble, when Priligy is taken continuously for 12 to 24 weeks for each sexual activity, about 25% of people at 30 mg and about 40% at 60 mg have an improvement effect. It has been reported that it was possible to realize it.

Impact of Priligy on clinical data

The effectiveness of Priligy in the treatment of premature ejaculation has been established in clinical trials. All clinical trials were conducted in men over the age of 18 who had a history of premature ejaculation for the majority of sexual activity during the last 6 months of participation in the clinical trial.

Patients with premature ejaculation who meet the DSM-IV diagnostic criteria, that is, patients with IELT within 2 minutes (measured with a stopwatch), poor control of ejaculation, and premature ejaculation conditions that interfere with stress and partner relationships. Those who were included and had other sexual dysfunctions, including erectile dysfunction, or who had already taken other medications for premature ejaculation were excluded.

A clinical trial of 1162 patients confirmed a significant prolongation of IELT in both the 30 mg and 60 mg groups, with nearly half of the patients having an IELT of 2 minutes or longer. The degree of IELT extension was very related to the original IELT, and individual differences were greatly confirmed.

The therapeutic effect of Priligy has also been demonstrated in terms of outcome indicators and responder analysis in various patient reports. In another clinical trial, patients were asked to feel the effect of Priligy 24 weeks after the treatment period, and about 30% of patients in both the 30 mg and 60 mg groups answered that they were “slightly good”.

How to take Priligy

Priligy is the world’s first oral-type premature ejaculation drug that is characterized by its rapid onset of effect. The effect begins to appear about 30 minutes after oral administration, and the effect is exhibited 1 hour later, so take the drug 1 to 2 hours before sexual activity. The duration of the effect is about 3 to 5 hours.

Priligy is not a medicine that you take every day, but medicine that you take every time you have sexual activity. It is not affected by food, so there is no need to adjust the timing of meals and medications. However, it is affected by alcohol, so please refrain from alcohol when taking Priligy.

Duration of action

Dapoxetine, the active ingredient of Priligy, is absorbed in rest after ingestion and reaches the maximum blood concentration (Cmax) about 1 to 2 hours after oral administration. Absolute bioavailability (the proportion of drugs that are also active in the systemic circulation after taking Priligy) is 42% (variation range 15-76%), and dose-dependent exposure at doses of 30-60 mg/dose. It was confirmed that (blood concentration-area under the time curve (AUC), Cmax) increased.

The effect of taking Priligy varies from person to person, but it appears about 30 minutes after taking it, and you can feel the sufficient effect in about 1 hour, and it is said that the effect lasts for 3 to 4 hours. The degree of effect is also confirmed in a dose-dependent manner, and those who are not effective at 30 mg/dose are allowed to increase the dose up to 60 mg/dose.

Eating a high-fat diet reduced dapoxetine Cmax by 10%, increased AUC by 12%, and slightly slowed the time to peak dapoxetine levels, but these changes are clinically significant. To a degree, Priligy does not need to consider the effects of diet.

After oral administration, blood levels of dapoxetine decrease with an initial half-life of about 1.5 hours, plasma levels are less than 5% of peak levels by 24 hours after administration, and elimination half-life is about 19 hours. Therefore, it is recommended to administer once every 24 hours.

How to take Priligy

The recommended dose will vary depending on the individual’s condition, but the recommended dose is 30 mg once daily 1 to 3 hours before sexual activity. After taking Priligy once, wait at least 24 hours before the next dose. This is to prevent the risk of developing side effects from increasing, and because it is difficult to obtain additional effects even if taken within 24 hours.

When taking, please take with a glass of water or lukewarm water. Priligy is not easily affected by meals, so it can be before or after a meal. However, it is affected by alcohol, so please refrain from drinking alcohol when taking Priligy. If 30 mg is inadequate, taking 30 mg does not cause any particularly moderate to severe adverse events, and there are no prodromal symptoms of syncope, the dose can be increased to 60 mg.

Priligy is a drug that is taken when needed, that is, before sexual activity, so it should be taken each time. Even if you miss a dose, there is no particular adverse effect on your body. If you overdose, you may need urgent medical treatment even if you do not have any abnormalities, unpleasant symptoms, or addiction symptoms. please.

Comparison with other premature ejaculation preventives

Priligy is the world’s first oral drug for the treatment of premature ejaculation. Prior to the launch of Priligy, the only premature ejaculation drug was a local anesthetic applied directly to the penis. By applying a local anesthetic directly to the penis, the hypersensitivity reaction to the sexual stimulation of the penis was suppressed, and premature ejaculation was prevented by blunting the stimulation.

There are various dosage forms of local anesthetics such as ointments, creams, lotions, and sprays, and condoms with local anesthetics applied to the male side can be selected according to the lifestyle, but only temporarily. It was a drug that prevented premature ejaculation by improving the hypersensitivity of the penis to sexual stimulation.

On the other hand, Priligy focused on the involvement of serotonin in ejaculation, and premature ejaculation patients had relatively low levels of serotonin in their brains, so noradrenaline was active and the penis became hypersensitive to sexual stimulation. It is a drug that aims to improve premature ejaculation by finding out what it has become and leading the chemical imbalance of serotonin concentration in the brain to a normal state.

It is possible to approach premature ejaculation physiologically from inside the body, and it has been recognized that if you continue to take it every time you have sexual activity, it will have a high improvement effect on premature ejaculation. It’s a great drug in that it allows for non-temporary treatment.

Side effects of Priligy

Side effects are when a drug does something other than its intended purpose, and every drug has some side effects. This is because the drug spreads throughout the body, not just at the site of the disease, and it is of utmost importance to adhere to the dosage and administration of the drug in order to reduce the risk of developing side effects.

Be aware that if you take more than the prescribed dose just because the medicine is not effective, the risk of side effects will increase dramatically. If you have allergies, be sure to read the ingredients contained in the medicine. Priligy generally has mild side effects, but if any of the following side effects occur, take measures such as seeing a medical institution.

Main side effects

The most commonly reported adverse reactions to include nausea, nausea, dizziness, headache, diarrhea, insomnia, and fatigue. If you experience these symptoms and feel anxious, consult your doctor or a nearby clinic. please.

Erectile dysfunction (difficult to erect or maintain an erection) as a reproductive system disorder, hyperhidrosis as a skin and subcutaneous tissue disorder, diarrhea, vomiting, constipation, abdominal pain, upper abdominal pain as a digestive system disorder, Digestion, intestines, stomach discomfort, abdominal bloating, dry mouth, sinus congestion, nasal congestion, vomiting as respiratory/thoracic and mediastinal disorders, red tide as vascular disorders, ear and inner ear diseases Ear ringing, fog vision as eye system disorder, eye pain, drowsiness, distraction, tremor, numbness as nervous system disorder, sleeplessness, anxiety, tension, decreased libido, depression, indifference as a mental disorder, etc. Side effects such as fatigue, irritability, and irritability as general diseases and administration site conditions, and increased blood pressure as other observed symptoms have been reported.

If you experience any of these side effects and feel any abnormalities in your body, please consult your doctor or medical institution.

Rare side effects

In clinical trials, seizures, orthostatic hypotension, orthostatic syncope, and postictal twilight have been reported while taking Priligy. If you experience any of these symptoms, stop taking Priligy immediately and consult a medical institution. In clinical trials, syncope, characterized by unconsciousness, has been observed in patients wearing Holter-ECG with bradycardia or sinus arrest and has been implicated in Priligy.

Since most cases occur within 3 hours after administration or after the first administration, it is necessary to pay particular attention to fainting and orthostatic hypotension at the time of the first administration and 3 hours after the administration. Syncope often develops with prodromal symptoms, especially in patients using higher-than-recommended doses, and is thought to be dose-dependent.

Prodromal symptoms include poor mood, dizziness, dizziness, confusion, sweating, and abnormal heartbeat. If you experience any of these symptoms, lie down, lower your head, sit down and put your head between your knees, and wait for your mood to improve. Also, be careful not to suddenly stand up while sitting or lying down.

Precautions when using Priligy

When taking Priligy, there are some people who should not take Priligy in the first place, and some drugs that should not be taken with PriligyApplicable persons and those taking applicable drugs should not take Priligy.

It can be very dangerous. In addition, there are other people who need to be careful when taking this medicine, and some medicines that require careful attention when used in combination with Priligy. If you are eligible or are taking any of these medications, consider whether you really need to take Priligy and consider the risks and benefits when taking it.

Also, when taking Priligy, be sure to carefully observe your condition, and if you notice any abnormalities, please consult a medical institution immediately.

People who are careful about taking

If you are allergic to other medicines, some foodstuffs, preservatives, or dyes, you may develop allergies even if you take this medicine, so please take it carefully.

  • Those with a history of dizziness due to low blood pressure
  • Those who have some kind of heart disorder
  • Those who have some kind of blood vessel disorder
  • Those who have a tendency to bleed
  • People with depression
  • Those who are prone to suicide or self-harm
  • Those with mental disorders such as schizophrenia
  • People with a history of mania (great excitement, hallucinations, lack of concentration, inability to stay still) or bipolar disorder (extreme mood swings)
  • Those who have developed both mania and bipolar disorder
  • Those with seizures or uncontrolled epilepsy
  • Those with severe renal dysfunction
  • Those with sexual dysfunction
  • Those with glaucoma

If you feel any abnormalities, stop taking Priligy immediately and see your doctor or medical institution.

Caution for combined use

First of all, if you are taking other medicines, these other medicines include not only prescription medicines but also supplements purchased at pharmacies, supermarkets, and health food stores, but always before taking Priligy. Make sure that you have no problems drinking.

Talk to your doctor before taking Priligy if you are using recreational medications such as aphrodisiacs, LSD, narcotics, or benzodiazepines.

Triptan preparations such as sumatriptan used for the treatment of migraine, tramadol for the treatment of pain, lithium for the treatment of mood disorders, blood thinning agents such as warfarin, hypertension, and chest pain (angina), and Therapeutic agents for prostatic hypertrophy, erectile dysfunction (impotence), anti-inflammatory agents such as ibuprofen and aspirin, antibiotics for the treatment of infectious diseases such as erythromycin and clarithromycin, therapeutic agents for nausea such as aprepitant, and sedation such as midazolam. The combination of the drug and the drug may have some effect on the efficacy of the drug or the drug.

Consider switching to other concomitant medications or adjusting the dose. If it is unavoidable to use it together, observe it carefully.

People who should not take

If you have any allergies to drugs containing dapoxetine, the active ingredient of Priligy, or if you are allergic to or have an allergic reaction to the ingredients contained in Priligy, you should not take Priligy.

Please check that Priligy contains lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate, etc. Allergic reactions here refer to shortness of breath, wheezing, difficulty breathing, swelling of the face, lips, tongue, rash, pruritus skin, and urticaria.

Those with severe heart failure (NYHA class II-IV), conduction abnormalities such as AV block or sinus node syndrome, marked ischemic heart disease, marked valve membrane disorder, history of fainting, severe manic or depressed Do not take Priligy if you have a medical history or have moderate to severe heart failure.

Men under the age of 18 and over the age of 65 should not take Priligy as their safety and efficacy have not been established. In addition, Priligy is a drug developed for men with premature ejaculation, and its safety for women has not been established, so women should not take Priligy.

Contraindicated drug

Do not use monoamine oxidase inhibitors (MAOIs) with Priligy for the treatment of depression. Also, if you have taken MAOI within the last 14 days, you should not take Priligy. Typical MAOI drugs include moclobemide, phenelzine, and tranylcypromine.

Do not take Priligy if you are using aldazine (generic name thioridazine) for schizophrenia or have taken it within the last 14 days. Those who are using SSRIs or other medications to treat depression, or who are taking serotonin-affecting medications or herbal products such as St. John’s wort, or taking these medications within the last 14 days. If you do, do not take Priligy.

Typical SSRI drugs include amitriptyline, citalopram, doxepin, fluoxetine, fluvoxamine, mianserin, mirtazapine, nortriptyline, paroxetine, and venlafaxine. People taking fungal infections such as ketoconazole, itraconazole, and fluconazole should not take Priligy. People taking antiretroviral medications such as ritonavir, saquinavir, and atazanavir should not take Priligy.

Generic drug of Priligy

For Priligy, which has been approved in more than 50 countries overseas, there is already a generic drug called a generic drug that contains the same active ingredient as Priligy and has been shown to have the same effect. Posette is a typical example.

In addition, many generic drugs containing the active ingredient dapoxetine are sold in combination with erectile dysfunction treatment drugs. It is a therapeutic drug that can treat both erectile dysfunction and premature ejaculation at the same time by combining the active ingredient of major erectile dysfunction drugs such as Viagra and dapoxetine, which is an ingredient to prevent premature ejaculation.

Since generic drugs are less expensive to develop than original drugs, they are characterized by their reasonable price and are recommended for those who want to be treated at no cost.

Development of Priligy Generic

Posette is a typical generic drug of Priligy. It contains dapoxetine, which is the same active ingredient as Priligy, and there are two types: 30 mg tablets containing 30 mg of dapoxetine and 60 mg tablets containing 60 mg.

Sold by Sunrise Remedies of India. Sunrise Remedies is a generic drug manufacturer founded in India in 1995 and has grown rapidly over the last 15 years. We mainly deal in medicines that are indispensable for sexual life, the offer price is low, and we manufacture medicines based on the manufacturing quality control standard of medicines called GMP, which is very popular.

It also incorporates the idea of ​​traditional medicine called Ayurveda in India, which is accelerating its popularity. Since Posette is a generic drug of Priligy, its effect is naturally equivalent to that of Priligy, and when taken about 1 to 3 hours before sexual activity, it has the effect of extending the time required for ejaculation by about 3 to 5 times.

It is known that the maximum blood concentration is reached about 1 hour after taking it, so it is most effective to take it 1 hour before sexual activity, and it is a drug that can be taken up to 60 mg per day.

Drugs that can be expected to improve ED

There are many generic medicines on the market that can treat premature leakage and erectile dysfunction at the same time by combining dapoxetine, which is the active ingredient of Priligy, and the active ingredient of erectile dysfunction treatment. As a drug containing sildenafil, which is the active ingredient of Viagra, which is synonymous with erectile dysfunction treatment, and dapoxetine, which is the active ingredient of Priligy, Superfildena, Dastra, and several other drugs are on the market.

In addition, there are Super Kamagra, which contains sildenafil and dapoxetine, which are the main components of Kamagra, and Tadalafil, which contains tadalafil and dapoxetine, which are the main components of Cialis. It has been reported that 1/3 of erectile dysfunction has premature ejaculation, and it is difficult to separate erectile dysfunction and premature ejaculation.

If you have both, we recommend that you try a drug that contains both the active ingredient of the erectile dysfunction treatment drug and the active ingredient of the premature ejaculation treatment drug. There are combinations on the market that contain the active ingredients of commonly known erectile dysfunction treatments and can treat both premature leakage and erectile dysfunction, so you are already using your own erectile dysfunction treatment. It is also a good idea to try a combination drug that contains the same active ingredients as the drug.

How to buy Priligy

Priligy is an unapproved drug in Japan. Therefore, the drug market in Japan, that is, the Ministry of Health, Labor, and Welfare has given permission to use Japanese people, and the route of distributing drugs from hospitals and clinics to general consumers has not been established.

Priligy is a prescription drug, that is, a drug that you receive at a dispensing pharmacy after receiving a prescription drug under the diagnosis of a doctor at a hospital or clinic, so you cannot purchase it at a drug store in the first place. Therefore, in order to obtain Priligy, it is necessary to obtain a prescription from a hospital or clinic that is already licensed overseas or ordered from overseas.

Priligy’s domestic prescription is free medical treatment

Priligy is not licensed in Japan. However, some clinics import and prescribe Priligy from overseas under the permission of the Ministry of Health, Labor, and Welfare. In Japan, the drugs approved by the Ministry of Health, Labor and Welfare are covered by the public medical insurance, health insurance, national health insurance, and the medical system for the elderly, and the medical treatment costs for doctors and pharmacists are the consideration specified by the Ministry of Health, Labor and Welfare. Medical fees calculated based on are also applicable.

Therefore, the out-of-pocket cost of general consumers is limited to 20 to 30% of the official medical fee set by the Ministry of Health, Labor, and Welfare. However, since public medical insurance and medical fees do not apply to drugs not approved by the Ministry of Health, Labor, and Welfare, medical practices and drug prices can be set arbitrarily by medical institutions, and the cost is fully borne by the patient. It will be. In general, the cost of treatment is higher when using an unlicensed drug than when using a licensed drug.

Currently, Priligy is not approved by the Ministry of Health, Labor, and Welfare, but some clinics are allowed to import and prescribe Priligy from overseas. However, it is a free medical treatment that is not covered by public medical insurance and medical fees. Many clinics publish their costs on their websites, so it is recommended that you check before you actually visit.

Not available at pharmacies and drug stores

Priligy is a prescription drug, which is prescribed by a doctor after being diagnosed, is dispensed by a pharmacist at a dispensing pharmacy based on the prescription issued by the doctor, and is distributed to general consumers. Also called a drug. Prescription drugs are designated as highly effective drugs.

On the other hand, highly effective medicines must be careful about side effects, and it is a medicine that requires the judgment of a doctor in order to be used by general consumers and is designated by the Ministry of Health, Labor and Welfare. Priligy is a drug that has not been approved by the Ministry of Health, Labor, and Welfare, but due to the status of approval overseas and the high effectiveness of the drug, it will be treated as a prescription drug.

Therefore, it is not available at general pharmacies or drug stores. By the way, medicines handled in general pharmacies and drug stores are said to be over-the-counter medicines. In addition, prescription drugs have been used for many years and once their safety has been confirmed, they are called switch OTC drugs and can be purchased at general pharmacies and drug stores.

At first, it is obligatory to receive an explanation from a managed pharmacist before purchasing a drug requiring guidance. In this way, the method of selling drugs changes with the establishment of safety and achievements.

Mail order situation of Priligy

To purchase Priligy, it is advisable to use a private import agency, which is an agent for personal imports of medicines in overseas markets. The method is almost the same as the mail-order company used for ordinary shopping, and access the homepage of the personal import agency.

The homepage has a lineup of medicines handled by the mail-order company, and you can complete it by selecting Priligy from them and pressing the purchase button. There are countless private import agents, but it is important to choose a reliable personal import agent from the vast number of them.

First of all, if you are worried about your language, please select a Japanese-speaking company or a Japanese company’s personal import agency. In addition, Japanese private import agents always obtain permission from the Ministry of Health, Labor, and Welfare. I think that it is stated on the homepage, so please check it.

One checkpoint for individual import agents based overseas is whether or not they only handle drugs that have been approved by overseas regulatory agencies. In addition, the number and content of word-of-mouth by users and the enrichment of content such as precautions for purchasing and shipping will also be a factor in making a decision. Please find your own convenient personal import agency.

Summary of Priligy

Priligy is the world’s first premature ejaculation prevention drug to be taken. It has already been approved overseas in more than 50 countries such as Europe and Asia and is used by many people. It has been reported that taking Priligy for each sexual activity has a high probability of over 70% improvement in premature ejaculation.

It is an easy-to-use drug that can be taken 1 hour before sexual activity. Unfortunately, it is not approved in Japan, but it can be obtained by private import. Improve premature ejaculation with Priligy and get fulfilling near-ideal sex.

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