PDE-5 inhibitors

pde5 inhibitors

The PDE-5 inhibitors were originally developed for the treatment of angina pectoris. In modern medicine, they are mainly used in the treatment of erectile dysfunction. This is also because they cause the blood vessels to expand.

What are PDE-5 inhibitors

PDE-5 inhibitors are also known as phosphodiesterase V inhibitors. These are substances that inhibit the effects of the cGMP-degrading enzyme phosphodiesterase V and thereby increase the concentration of intracellular cGMP.

Statement on cGMP

cGMP is a cyclic guanosine monophosphate, also called cyclic GMP, cyclo-GMP or cGMP for short, and thus a second messenger or a cellular messenger that is responsible for the transmission of signals in the cell. This creates a signal transduction. This is required for the best possible visual process, which takes place in the rods but also in the cones of the retina. It also serves to relax smooth muscle tissue and blood vessels. The regulation of the insulin level is also influenced by the signal transduction.

The PDE-5 inhibitors were originally developed for the treatment of angina pectoris. In modern medicine, they are mainly used in the treatment of erectile dysfunction. This is also because they cause vasodilation (widening of the blood vessels). Therapeutic approaches with PDE-5 inhibitors also take place in the clinical picture of pulmonary hypertension.

Explanation of the term erectile dysfunction (ED)

ED is also known under the names erectile dysfunction, erectile dysfunction or simply impotence.
Latin: Impotentia coeundi; brought about from the Latin coire = to go together or mate. In simple terms: in most cases it is not possible for a man to achieve or maintain an erection on his penis. A satisfactory sex life is usually not possible with it. Temporary erectile dysfunction is not considered erectile dysfunction.

The mechanism of action of phosphodiesterase V inhibitors

As inhibitors of phosphodiesterase V, the PDE-5 inhibitors are responsible for the breakdown of intracellular messenger substances, the second messengers. In the process, cGMP is selectively broken down. For this purpose, cGMP itself is activated by an endothelial relaxation factor (nitrogen monoxide). Thus, cGMP is involved in the relaxation of the blood vessels. Together with the inactivation of cGMP by the PDE-5 inhibitors, the effect of nitric oxide is increased and, as a result, the vasodilating effect is increased. And it is precisely this mode of action that is adopted in erectile dysfunction from a pharmacological and medical point of view.

Other important information

Phosphodiesterase V inhibitors always require a prescription. Interactions with other drugs as well as allergies and intolerances must be clarified with the attending physician. A doctor’s consultation is also required, for example, in the case of heart disease and if blood-thinning agents are already being taken. The same is true with regard to psychiatric drugs.

How do PDE-5 inhibitors work?

PDE-5 inhibitors are substances that inhibit the formation of the phosphodiesterase-5 enzyme in the body and thus also the breakdown of cyclic guanosine monophosphate caused by this enzyme.

Pde-5 and PDE-5 inhibitors

cGMP (cyclic guanosine monophosphate) is a cellular information carrier that is used in the body, for example in the visual process, in regulating the insulin level, etc. In the smooth muscles, cGMP causes relaxation and thus an expansion of the blood vessels. – Phosphodiesterases (PDE) are cGMP-degrading enzymes and are numbered from 1 to 11. PDE-5 is interesting here. Located in the smooth muscles of the penis and in the lungs, it regulates blood supply in both cases. In the lungs, PDE-5 causes a reduction in pressure. This know-how is used by the pharmaceutical industry in Pharmaca such as Sildenafil, which contains substances that inhibit PDE-5 in pioneering branded products such as Viagra.

How do PDE-5 inhibitors work?

The healthy male body continuously produces PDE-5, which breaks down cGMP into 5-GMP by breaking the phosphoric acid ester bond. As a result, for example, the blood supply to the penis is blocked and the penis becomes flaccid. If the cGMP cleavage is inhibited, the cGMP concentration is increased for a short time. 

When a healthy man is sexually stimulated, the brain causes an increased production of PDE-5, which inhibits the formation of cGMP and results in an increased blood supply to the penile erectile tissue. 

The arteries in this area swell and the veins are squeezed, causing the blood to back up and not drain. An erection occurs. In erectile dysfunction, this process is disturbed and this is where PDE-5 inhibitors are used. 

Studies confirmed that PDE-5 inhibitors very successfully inhibit the production of phosphodiesterases in the area of ​​the erectile tissue of the penis, so that the secondary information carriers cGMP can be produced in this limb unhindered and an increased blood supply is made possible in this area.

PDE-5 inhibitors are also used in pulmonary arterial hypertension. This condition occurs when the mean pressure in the pulmonary artery due to Pde-5 rises too much above the normal value and results in reduced physical performance, which is expressed in a number of diseases that are characterized by fatigue, because it is The inner diameter of the pulmonary arteries is reduced and thus less bound oxygen is transported. 

The targeted use of PDE-5 inhibitors can counteract this, by inhibiting the formation of PDE-5 and thus increasing cGMP production. The latter then causes the increased blood flow to the lung tissue.

Available PDE-5 inhibitors

Nowadays there are a number of different pharmaceutical and homeopathic preparations that contain PDE-5 inhibitors, but differ in their composition, concentration and duration of action.

Potency drugs with the ingredient PDE-5 inhibitor

Viagra (active ingredient: Sildenafil), Spedra ( Avanafil ), Levitra (Vardenafil) and Cialis (Tadalafil) all belong to the group of so-called PDE-5 inhibitors. The preparations mentioned are a completely new generation of potency enhancers.

PDE-5 inhibitors or phosphodiesterase-5 inhibitors are substances that inhibit a certain enzyme that is responsible, among other things, for the expansion of blood vessels. Originally, the aforementioned agents were developed for the treatment of constricted blood vessels in the heart region, until the bizarre side effect was noticed, which led to another commercialization.

The visit to the doctor

The preparations differ in terms of their onset of action, the duration of action and the dosage. But they all work equally well. However, a visit to the doctor is urgently indicated in advance because not every patient can simply take such drugs without risk. Usually, the drugs mentioned cannot be obtained without a prescription. The interactions with other drugs or possible heart problems are contraindications and will probably lead to the fact that you do not get the drug. The risk of serious side effects is then simply too high. The health insurance companies speak a clear language when it comes to potency: Drugs that are intended to treat erectile dysfunction are not covered and must be borne by the patient himself.

Side effects

Since the preparations are very similar in terms of their chemical composition, the side effects are almost equally distributed. Common side effects are headaches and facial flushing. These unpleasant side effects can occur due to the improved blood circulation. Digestive disorders can also be the result of improved blood circulation. Back pain and visual disturbances are rare.

A doctor should be consulted, especially if other medications are also being taken. Substances such as amyl or butyl nitrite substances pose a great danger. They are also commonly called “poppers”. The mixture resulted in deaths after Viagra was approved.

Herbal PDE 5 inhibitors

In principle, herbal sexual enhancers are to be seen as an alternative to pharmaceutical sexual enhancers. Unfortunately, unlike a prescription PDE-5 inhibitor, free herbal sexual enhancers (over the counter) have only rarely been tested in medical studies.

Different natural sexual enhancers as an alternative to a PDE-5 inhibitor are listed below. Likewise the suspected or proven effectiveness.


This substance is found in the sperm whale in the gray amber. Ambrein enjoys a high reputation for increasing potency, especially in Arab countries. The effect is based on the stimulation of various endogenous “production facilities” for the required hormones. This leads to an increased release of testosterone in the male body. This increase ultimately leads to an improvement in libido. This can then lead to the desired erection.


This substance is found predominantly in mushrooms. But it could also be detected in the skin secretion of different toad species. The substance butofenine works in the head. That is why it is said to have a central increase in sexuality and sexual pleasure.

Cantharidin (Spanish fly or also called Kantharidin)

The “Spanish fly” is ground to obtain it. Hence the second name. The agent is just as suitable for oral ingestion as it is for external use with direct application to the external genitalia. Longer lasting erections should be possible.


This substance is obtained from the group of vegetable leeks. It should be able to increase both the number of coitus and the ejaculation frequency.


Various sub-forms are known here. The Alpinia Calcarata is said to have a positive effect on sexuality. It belongs to the ginger family and apparently not only stimulates erectile function but also the libido.

Perennial Bertram (Latin Anacyclus Pyrethrum)

The perennial Bertram is a plant belonging to the marigold genus. The active ingredient is said to have a vitalizing effect on erectile functions.


Even before the PDE-5 inhibitor was developed, yohimbine was very important in the treatment of erectile dysfunction. The substance is obtained from the leaves of the yohimba tree. It was discovered by natives of Africa. You chewed on the bark of a tree to increase your erectile chances. The statements of the available studies on effectiveness vary widely.


Ginseng is also known under the name Samwurzel or Kraftwurzel. A distinction is made between red and white ginseng. The Asian variants are best known in Germany. The root is said to improve erectile function. Ginseng can also be taken for prophylaxis.

Tribulus Terrestris

This substance is one of the best known. It is obtained from the root of the earth . This substance is known as a “natural anabolic steroid”, especially in the field of sport and fitness.


This is a well-known amino acid. Positive effects are described in relation to the smooth muscles of the erectile tissue. An improved erectile function is achieved. Sometimes arginine is mixed with other substances. This is intended to achieve an even better effect.


This substance is mainly found in the Andes of Peru. This substance is also often used as a dietary supplement. It is obtained mainly from the dried tuber powder.

PDE-5 inhibitors without a prescription

If you suffer from impotence, too, there is little need to worry. Surely you feel restricted in your manhood and you can also face some emotional stress, but there is a very effective remedy for impotence. So-called PDE-5 inhibitors have been used against impotence in men since 1998. There are now numerous different potency pills with a wide variety of ingredients. According to various statistics and studies by experts and doctors, however, the PDE-5 inhibitors are the most effective potency pills there are. A long-lasting erection is achieved with the first intake of the potency pill. The exact dosage of the tablet indicates how long the effect will last.

Potency pills without prescription from the Internet

It is true that one hears again and again that the potency pills or the PDE-5 inhibitors are only available with a prescription, but this statement is not entirely true. The original products can now also be bought and ordered on the Internet or in online pharmacies. No prescription is required for this and the shipment is also relatively quick. The only disadvantage is that there is no personal and detailed consultation with a doctor. Men have to fill out a questionnaire about their health beforehand, but of course the information cannot be checked to ensure that it is correct.

It should also be noted that the potency pills without a prescription from the Internet are associated with higher costs. An average of € 50.00 is charged for 4 tablets. PDE-5 inhibitors are much cheaper with a prescription. However, since many men want to keep impotence a secret, they are happy to take on the higher costs. Anyone who orders potency pills from the Internet should stay away from cheap products from the Far East. These tablets are certainly a waste of money and in no way achieve the same effect as the original products.

The effect in detail

The potency pills should be taken with a glass of water and so that the desired success (erection) is achieved, the intake should be taken about 30 to 60 minutes before the planned sexual act. One advantage is that the erection does not occur until there is sexual stimulation. After the man climaxes, the erection will slowly subside. Depending on the dosage and type of potency pill, the effect lasts for several hours. A single potency pill a day should therefore be completely sufficient. In the case of over-the-counter potency pills from the Internet, the manufacturer’s instructions for use should be followed in any case.

Side effects of PDE-5 inhibitors

The potency pills achieve an excellent effect in the area of ​​erections, but men also have to reckon with side effects again and again. Very often, however, the symptoms are limited to tiredness, headaches or diarrhea. A stuffy nose (runny nose) can also be related to the use of potency pills. If the symptoms persist after a few days, medical advice should be sought. Unfortunately, these side effects are very common in men and unfortunately cannot be avoided. Men who suffer from cardiovascular problems should refrain from taking potency pills for safety’s sake or clarify and discuss the intake with an experienced doctor beforehand.


Potency pills can be ordered over the Internet without any concerns. Men should, however, consider the delivery time and thus always have a certain amount of supplies at home.

PDE-5 inhibitors do not work

PDE-5 inhibitors are the first choice when the diagnosis of erectile dysfunction is an issue. While Viagra often has dangerous side effects, and in some cases has been blamed for the death of some users, the mode of action of PDE-5 inhibitors is very subtle in comparison. This can also be due to the fact that the function of the PDE-5 inhibitor starts elsewhere. Despite their sensitive mode of action, PDE-5 inhibitors also have critics in tow.

Experience reports from users are circulating on the Internet, according to whose statements PDE-5 inhibitors do not work or work insufficiently. In this context, it is perhaps important to know that these preparations do not act directly on the penile muscles, but on the messenger substances that ultimately trigger the erection. In contrast to Viagra – which has a direct influence on the blood vessels, vardenafil or tadalafil inhibits a neurotransmitter in favor of another messenger substance. To put it very simply: Vardenafil requires sexual arousal. A result can only be achieved after sufficient stimulation, and that is a fully erect penis. After the sexual union and the decrease in arousal, the erection also returns to normal.

Is skepticism appropriate?

Do you still need to be restrained when taking Sildenafil & Co.? PDE-5 inhibitors require a prescription and any doctor will use care before prescribing them. Only when a heart disease or chronic high blood pressure can be ruled out is a prescription issued for the preparation. It should also be noted that there is a delayed effect with constant consumption of high-fat foods. The intake should take place 60 minutes before the planned sexual intercourse; the subsequent effects last up to four hours. This does not mean that the penis remains erect for up to four hours, but that sexual arousal in this period of time stiffens. According to the manufacturer, this applies to 82% of users. In around 18% there may be only to an erection, or there will be no success. In this case, the family doctor must be informed. In many processes, it is not the physical, but the emotional component that triggers erectile dysfunction.

Drug (sexual enhancer) with PDE-5 inhibitors

A very important component of potency pills is the PDE-5 inhibitor. It ensures that erectile problems in men can be treated very effectively and, roughly speaking, is responsible for positively influencing the blood flow and thus stimulating the erectile tissue. An additional advantage is that the outflow of blood from the male member is slowed down when taking the potency pill and thus a permanent or long-lasting erection is the result. The potency pills, like medication, require a prescription and are not available in a conventional pharmacy without a prescription. However, if you want to avoid going to the doctor, you have found a very good alternative in the online pharmacies on the Internet.

Order PDE-5 inhibitors online

For many years, potency pills have also been increasingly ordered over the Internet. Many manufacturers and providers have smelled big money with potency pills and promising drugs and affected men were sucked the money out of their pockets, so to speak. Pills with the name “Sexgott” or “Hard as Steel” are common for sexual enhancers from the Internet, but they usually do not work. If you are looking for a reliable preparation to get an erection, you cannot avoid PDE-5 inhibitors. When ordering on the Internet, you should therefore pay more attention to what ingredients are in the pills or tablets.

The effect of potency pills

Potency pills are taken with a glass of water, similar to medication. It is very important that you pay attention to the duration of the effect. In most cases, the PDE-5 inhibitor should be taken about 30 to 60 minutes before the planned sexual act. If you have to go faster, there are of course also potency pills that spread their effects in about 15 minutes. However, sexual stimulation is necessary to achieve an erection. It is therefore impossible that the male member is aroused without sexual contact or without any erotic fantasies. The effect of the potency pills is about 12 hours or longer.

Note the maximum amount

In order to prevent health problems, the exact intake instructions of the manufacturer should be observed. However, if an overdose occurs, a doctor should be consulted as soon as possible. In general, however, the potency pills are very well tolerated and side effects are relatively rare. Headache or diarrhea are common. However, these diseases subside on their own after a short time.

PDE-5 inhibitor drugs

In summary, it can be said that the potency pills help a lot of men to get an erection again. The effect is very positive and lasts for a very long time. It is taken in the form of tablets and there are no known serious side effects. Affected men can easily order the potency pills over the Internet or contact a trusted doctor. The potency pills with PDE-5 inhibitors are the most effective preparations available in this field and are therefore definitely to be recommended. Regardless of whether it is prescribed by a doctor or from an online pharmacy, the instructions for taking it should always be observed and adhered to.

Numbers health insurance companies PDE-5 inhibitors

PDE-5 inhibitors became known worldwide through an accidental discovery in clinical research. Because Viagra, also called the blue miracle pill, went around the world. The active ingredient sildenafil was thus the first to be used to treat erectile dysfunction (ED). Then came Tadalafil, Vardenafil and Avanafil. They are available as the best tried and tested means in therapy. The effectiveness has been confirmed in numerous studies. The effect on erectile dysfunction was tested on different patient populations. The PDE-5 inhibitor is the most popular drug for impotence.

Is the blood circulation correct – Is the erection correct

If the erectile dysfunction (ED) has an organic cause, this is due to a narrowing of the blood vessels. If there is no more blood flow in the penis, this leads to relaxation. With Viagra and Co. the blood circulation is stimulated again. Because in the erectile tissue of the penis, the blood circulation is stimulated. As a result, an erection can take place again. As a result of the vasodilation of the PDE-5 inhibitor, satisfactory sexual intercourse and orgasm take place. Incidentally, it does not increase sexual desire as this is not an aphrodisiac . This only enables interaction with sexual arousal and stimulation.

Erectile dysfunction (ED)

It is known to many men and has far-reaching causes. Organic triggers such as diabetes , high blood pressure and arteriosclerosis then lead to vasoconstriction due to their effect. But the psychological component cannot be ruled out either. Depression, stress, fear of loss and failure can cause erectile dysfunction. Accidents such as spinal cord injuries as well. This is where the so-called PDE-5 inhibitors can show their effects. These must be prescribed by the doctor in treatment-related cases.

Health insurance companies pay PDE-5 inhibitors

This always depends on the area of ​​application. Because the phosphodiesterase (PDE) -5 inhibitors can only be covered by the health insurances if a diagnosis, cause and treatment by the doctor or specialist is available. As a rule, this person can then issue a prescription from a statutory health insurance physician. The focus here is always on recovery and not on improved quality of life. Since 2004, Viagra and Co. have been known as “lifestyle drugs”. Since then, the costs are no longer covered by the health insurances. However, treatment and effectiveness have been proven and confirmed. In the event of illness, however, the active ingredient is covered by the health insurance company, otherwise it is issued via a private prescription. These costs are then paid in full by the patient. Since the active ingredient requires a prescription,

PDE-5 inhibitors homeopathic

In principle, homeopathic sexual enhancers should be viewed as an alternative to PDE-5 inhibitors.
Unfortunately, the over-the-counter homeopathic sexual enhancers have rarely been tested in medical studies in comparison with a prescription PDE-5 inhibitor. In the following, different homeopathic sexual enhancers are mentioned as alternatives to a PDE-5 inhibitor. In addition, the suspected or proven effectiveness.


This substance can be found in the gray amber of the sperm whale. In Arab countries, Ambrein enjoys the highest reputation for increasing potency. The effect is based on the stimulation of different endogenous “production facilities” that are required for hormone production. This can lead to an increased release of testosterone. This increase then leads to an increase in libido and the occurrence of the desired erection.


This substance is found predominantly in mushrooms. But it was also found in the skin secretion of various toad species. Because of the effect in the head, it is said to have a central increase in sexuality but also in sexual pleasure.

Cantharidin (“Spanish fly” also called Kantharidin)

The “Spanish fly” is ground to produce it. The product is suitable for oral ingestion but also for external use directly on the genitalia. There is talk of longer lasting erections.


Alliaceae is obtained from a vegetable leek. It should not only increase the number of coitus but also the ejaculation frequency.


Various sub-forms are known. Alpinia Calcarata is associated with a positive effect on sexuality. It belongs to the ginger family and stimulates both erectile function and libido.

Perennial Bertram (Latin Anacyclus Pyrethrum)

This plant is a genus of marigolds. Many say that the active ingredient has a vitalizing effect on the erectile functions.


Even before the PDE-5 inhibitor was developed, yohimbine (Yohimbin Vitalcomplex Hevert®) was very well known in the treatment of erectile dysfunction. Yohimbine is obtained from the leaves of the yohimbine tree of the same name. Natives of Africa discovered the effect while chewing on the tree bark. The statements of the available studies on effectiveness vary widely.


Ginseng is also known under the name Sam- or Kraftwurzel. A distinction is made between red and white ginseng. In Germany, the most famous varieties of ginseng are Asian. The root promises to improve erectile function. Ginseng can also be taken prophylactically.

Tribulus Terrestris

This substance is one of the most well-known and is obtained from the pounded thorn plant. It is particularly popular as a “natural anabolic steroid” in the area of ​​sport and fitness.


Arginine is a very well known amino acid. Positive effects are known on the smooth erectile tissue muscles with better erectile function. Sometimes other substances are added to improve the effect.


This substance can be found in the Andes of Peru. Often this substance is also used as a dietary supplement. It is usually obtained from the dried tuber powder.

Other homeopathic preparations are

  • Vitex agnus castus ( Emasex -A vitex® with the active ingredient
  • Vitex agnus-castus Trit. D2
  • Virilis-Gastreu® S R41 with the active ingredient
  • Acid. phosphoricum, Agnus castus
  • Damiana (Virilis-Gastreu® S R41 with the active ingredients
  • Acidum phosphoricum (homeopathic) Dil. D12
  • Agnus castus Dil. D8
  • Damiana (homeopathic) Dil. D6

PTAs or pharmacists may recommend the following substances without a prescription:

  • The homeopathic active ingredient Damiana ( Cefagil ®) for sexual weakness
  • Agnus castus from the fruits of monk’s pepper or chaste mud for sexual
  • Acidum phosphoricum for mental, physical and sexual weakness or
  • A combination for self-medication from Acidum phosphoricum, Damiana and Agnus
    castus. As a complex agent under the name Virilis-Gastreu® S R41 in the med. Commercially
  • The combination of Agnus castus and picric acid in Viragil® is also suitable

PDE-5 inhibitors generic

PDE-5 inhibitors have been world-famous since 1998. The power pill Viagra, which brought many men the blue miracle in a pleasant way. Since the patent protection expired in June 2013, the way is clear for generics. These are copies of the original preparations with the same active ingredient. With regard to the production and the auxiliaries they contain, these are different. The main active ingredient is still identical. The large number of new potency pills gives users the opportunity to choose from different preparations, which was not the case before.

Potency problems are not an isolated case

How erectile dysfunction occurs varies. Erectile dysfunction is often a secondary disease. The interaction of blood vessels, hormones, muscles and the nervous system play a particularly important role. If these are intact, circulatory disorders gradually occur. The penis no longer becomes stiff and sexual intercourse is no longer possible. Vasodilating agents can help here. A healthier lifestyle should also be adopted. Fatty foods, alcohol and nicotine are conducive to vasoconstriction.

What are PDE-5 Inhibitors?

Due to their relaxing effect, they supply the erectile tissue in the penis with blood. This largely leads to an erection. Because the phosphodiesterase 5 inhibitor has a vasodilator effect. That is why the PDE-5 inhibitor is used successfully in erectile dysfunction (ED). The stimulated blood circulation enables the sensation of pleasure to be increased again. It must also be ensured that sexual stimulation always precedes it. Because the drugs to increase potency are not aphrodisiacs.

Generic drugs are cheap and effective quickly

The way is clear for the cheaper potency pills such as Spedra, Levitra, or Cialis. In terms of their active ingredient function, they are faster, longer-lasting and more tolerable than their predecessor Viagra. They can be taken as a therapy option for erectile dysfunction. This is also possible in the long term with a minimum dosage. The tried and tested active ingredient Sildenafil has been partially replaced in the generics by Tadalafil, Vardenafil and Avanadil. They also belong to the group of vasodilating agents. Likewise, the advantages of lower costs cannot be ignored. Because in some cases they are only a third of the original preparation. Thus the copies with the same active ingredients are a new achievement for the world of men.

But why are generics cheaper than branded products?

There are no development and research costs for the PDE-5 inhibitor. Because the first-time suppliers often test the ingredients and effects for years until they are approved on the market. The treatment goal is always the same. It is used for erectile dysfunction (ED) with psychogenic, organic and mixed causes.

The market is booming

The PDE-5 inhibitors have become an indispensable part of German bedrooms. Due to the loss of patent protection for Viagra and the cheaper generics, the sales volume has tripled. And the men are satisfied with the preparations with the same active ingredients. This became known through the information for use and specialist information (EMA 2014). In high-quality studies, the PDE-5 inhibitors have proven to be reliable and highly effective helpers for men. Above all, the correct intake with sufficient non-alcoholic liquid is crucial. Fatty foods can also delay the effect. The popular generics are and will remain the first choice sexual enhancer and have conquered the potency sky.

PDE-5 inhibitor experience

A group of active ingredients that is very often used in the field of sexual enhancement drugs are the PDE-5 inhibitors. Although this remedy was originally researched to help relieve sore throats, it is now mainly used in this area. But what exactly should be considered in this regard in order to achieve good results? And how good are the chances of the successful use of these drugs in erectile dysfunction?

Great chance of success

First and foremost, it should be noted that the chances of successful use of PDE-5 inhibitors are basically very high. It is particularly noticeable that there are not that many men who do not react to it at all. The effect is primarily based on the inhibition and blocking of the enzyme phosphodiesterase V. This is responsible for some processes in our body, including the breakdown of cGMP. This substance now accumulates more and more in the body with the use of PDE-5 inhibitors. If the desired concentration in the blood is reached after a while, the vessels expand. The blood vessels are widened due to the cGMP, so that the blood flow is increased. In the course of this, the desired erection occurs in the area of ​​the penis.

When using it, it is important to ensure that the recommended dosage of the drug is adhered to as precisely as possible. The simple reason for this is that this is the only way to benefit from the effect and at the same time not have to complain about any side effects. If the desired effect is not apparent when using the recommended dose, it is not recommended to simply increase the dose on your own. This, too, should only be done in consultation with a doctor or pharmacist. But if you pay attention to these things, at least your own health is not at risk.

Unequal working times

At the time of onset of the effect, however, there are some discrepancies in the statements made by men who have already tried to treat their erectile dysfunction in this way. The main reason for this is that every organism reacts to the intake of the active ingredients in a slightly different way. So it is worth doing some tests before using it. This makes it possible to test how long it takes the body to react to the drug in the desired way. 

Because it is precisely the timing that is very beneficial in the successful use of sexual enhancers like these. With most drugs that contain PDE-5 inhibitors, the highest concentration of the active ingredient in the blood occurs after about three quarters of an hour to an hour. During this period, the sexual arousal is highest according to your own feelings. Although the curve flattens out again in the next few minutes and hours, the effect can still be felt for up to six hours. Then the level of cGMP in the blood normalizes again, which leads to the narrowing of the blood vessels to the normal level.

Long-term therapy with PDE-5 inhibitors

If men suffer from impotence, you want to get better soon – unfortunately the subject of erectile dysfunction = erectile dysfunction (ED) is still a taboo subject, so that those affected are ashamed to talk to their partner about it, let alone to confide in a doctor – although this often helps could. The causes are very different, mostly psychological, but physical causes such as undiscovered diseases can be behind it.

Doctors create studies with 39 participants

Doctors from Berlin and specialists from Mexico have thought about it and invited 39 study participants to take comparable long-term therapy with sexual enhancers. PDE-5 inhibitors offer an option for existing potency problems. The result is that patients with so-called erectile dysfunction are recommended to take phosphodiesterase 5 inhibitors in low-dose long-term therapy.

What is PDE-5?

Phosphodiesterase-5 = PDE-5 is an enzyme that has to be influenced in its effect, has to be practically inhibited. Pathophysiologically speaking, there is a lot in favor of long-term therapy with this drug in the case of impotence, says Professor Rubio-Aurioles, for example, who comes from Mexico and has agreed to take part in the research project in Berlin. PDE-5 inhibitors inhibit, i.e. suppress the enzyme.

PDE-5 improves erectile dysfunction in the long term

In order to achieve an improvement here, good so-called penile endothelial function is required. As evidenced by his experiments, all the findings indicated that a well-adjusted PDE-5 long-term therapy can improve and remedy erectile dysfunction in men in the long term. In further clinical studies it became clear that long-term treatment with PDE-5 inhibitors increased potency in the long term, and more so than with prescribed reliever therapy.

Three more studies with 300 men

Rubio-Aurioles presented three placebo-controlled studies at an event in Berlin at the European Urology Congress, in which a total of around 300 men took part. The PDE-5 inhibitor called Tadalafil Cialis® was used in this tried and tested long-term therapy. The daily dosages administered were 2.5 and 10 mg per day. The three studies then showed that the effect of the inhibitors in long-term therapy was very similar to the treatment required in each case. As a rough rule of thumb, 5 mg of tadalafil administered daily have approximately the same effect as 10 to 20 mg a day if required.

PDE-5 inhibitors also suitable for diabetics

What emerged particularly from the three studies by the experts was that the long-term therapy is also very effective in diabetics, so it is ideally suited for restoring a good penile erection in men. One of the three studies was only confirmed by diabetics. For them, on-demand ED therapy is usually particularly difficult. With the use of long-term therapy, similarly high success rates were achieved as with non-diabetics.

Quality of life increases with satisfactory sex

But this approach can also have its advantages psychologically: When tadalafil is administered, due to its longer half-life, a good long-term therapy with just one dose per day is possible. These are the words of Rubio-Aurioles. Thus, the problem of medication before the sexual act is practically eliminated. The quality of life of those affected improves and a beneficial side effect should be mentioned: by taking these PDE-5 inhibitors, the vessels of the entire body of the man are better protected against the insidious disease atherosclerosis.

Dosing of PDE-5 Hermmern

In 1998, the first PDE-5 inhibitor, sildenafil, was introduced to treat erectile dysfunction. Since then, the various potency pills have already helped numerous men to achieve a long-lasting and reliable erection. As a rule, the PDE-5 inhibitors require a prescription and their use should be clarified and discussed with a doctor in advance. Since this is a very strong medication, under no circumstances should an overdose occur, as otherwise serious damage to health or discomfort can emerge.

Dosage PDE-5 inhibitors

More and more men (including young ones) suffer from erectile dysfunction. Most of the time, this is due to an unhealthy and stressful lifestyle. If a change in diet and a break from stressful everyday working life do not help, potency pills are certainly the last resort. The PDE-5 inhibitor ensures that the blood flow to the erectile tissue is promoted and, in addition, it is achieved that the blood flow is slowed down with the use of potency pills. However, it is extremely important that the exact guidelines for ingestion are followed. The ingredient of the potency pills has a different duration of action and can last for several hours. Therefore, under no circumstances should you take more than one pill a day.

Taking PDE-5 inhibitors

The taking of potency pills is usually not subject to a specific time of day or night. Depending on the preparation, it should be taken about 30 minutes before the planned sexual intercourse. The pills should be taken with sufficient liquid (water). The active ingredient spreads relatively quickly and ensures a very good erection. In over 90 percent of men, a very good erection is achieved with the use of PDE-5 inhibitors.

Side effects of the potency pills

Although the sexual enhancers and potency pills bring the desired success of a long-lasting erection, unfortunately men have to accept some side effects or discomfort for this. Headaches, gastrointestinal problems or a stuffy nose are very common. The side effects are of course relatively harmless and subside completely after a few hours. However, if the dosage is too high or the potency pills are taken, a painful permanent erection or even heart problems can come to the fore.


In summary, it can be said that PDE-5 inhibitors are almost harmless when taken correctly. The effects are fantastic and it definitely helped a lot for men with erectile dysfunction. It is only important that the exact instructions given by the manufacturer or the doctor are complied with.

PDE-5 inhibitors despite pulmonary hypertension

Pulmonary hypertension doctors are now using the still unknown PDE-5 inhibitor for treatment.
Pulmonary hypertension – what is it actually? Pulmonary hypertension is also known as pulmonary hypertension. With pulmonary hypertension, chronic symptoms appear in the pulmonary circulation. In fact, the blood pressure is permanently increased, so there is hypertension in the affected patient.

As the disease progresses, the oxygen supply in the body is reduced. This results in poorer performance. Various factors cause lung vessels and heart muscles to grow. As a result, the heart muscle rapidly loses its elasticity, less blood is transported, vessels constrict and their walls thicken. In this disease, a more unusual substance is now used to slow the progression of pulmonary hypertension. The PDE-5 inhibitor. PDE – 5 inhibitors, also known as phosphodiesterase – 5 inhibitors, are a group of drugs that are used to treat erectile dysfunction, also known as impotence.

In this case, PDE-5 inhibitors ensure that a substance called cGMP is broken down more quickly, which means that the process of premature relaxation of the limb should be prevented. What does the phosphodiesterase 5 inhibitor have to do with the treatment of pulmonary hypertension?
PDE-5 inhibitors have a strong influence on the blood and its components. PDE-5 inhibitors include Slidenafil or Tadalfil. Ingredients of sexual enhancers. At this point, these can be taken in the form of a tablet by an affected patient. Due to the active ingredients it contains, both sildenafil and tadafil may have an impact on the blood vessels. They ensure an expansion and in this case help to regulate and reduce the existing pulmonary hypertension.

This counteracts the existing hypertension and slows down the process of vascular narrowing or thickening. The heart muscle also retains its current elasticity. Some of these funds are freely accessible and can be obtained without a prescription.

PDE-5 inhibitors and the risks

The success of the PDE-5 inhibitor is undisputed. The drug dilates the blood vessels and thus supports the erection. The advantage of this group of drugs is that they work quickly. On the other hand, men with cardiovascular problems take it at risk.

PDE-5 Inhibitor Alternatives

Natural sexual enhancers are a suitable alternative to PDE-5 inhibitors. Made from 100% natural substances, these products have no side effects. All natural sexual enhancers improve blood circulation and adjust testosterone levels. Many men generally feel better after taking herbal sexual enhancers. This method of treatment takes patience. It can take weeks for the desired effect to occur.

In many online shops, natural sexual enhancers with a quick effect are offered. Beware: Sidenafil is in these products. This active ingredient puts a strain on the heart and circulation and is not suitable for everyone.

Advantages and disadvantages of herbal sexual enhancers

The alternatives to the PDE-5 inhibitors are arginine, orthinine and taurine. It has amino acid in arginine and is often used by athletes. Taurine and arginine promote blood circulation, arginine also balances testosterone levels. The most popular alternative is called gingeng. The root from Southeast Asia has been used successfully for years to promote concentration. Gingseng is also very suitable for potency problems, as the vessels are widened and the blood circulation is promoted. 

Herbal sexual enhancers are 100% natural and therefore have no side effects. This also reduces the risk of allergies to a minimum. Herbal sexual enhancers can also be used for high-risk patients with cardiovascular problems. Should one tablet too much be taken,

Herbal sexual enhancers are available over the counter in all pharmacies or discreetly from a certified online shop. The only and major disadvantage of the herbal alternative is patience. Herbal remedies only work after prolonged and regular use. But when weighing the benefits and risks, the herbal sexual enhancers have a clear advantage over the PDE-5 inhibitors.

Side effects of PDE-5 inhibitors

The PDE-5 inhibitors, the prescription sexual enhancers, can, as is the case with all drugs, also have undesirable side effects or interactions. The reason for this is that the muscles not only relax in the erectile tissue of the penis, but also in other vessels and organs. Everything you need to know about the side effects is explained below.

General side effects

Possible side effects of PDE-5 inhibitors include headache, dizziness, drowsiness, ringing in the ears, or a stuffy nose. Gastrointestinal disorders can also occur. With regard to the cardiovascular and vascular systems, facial redness, an accelerated heartbeat or palpitations are possible. Visual disturbances have also been described, for example blurred vision, increased sensitivity to light, impaired color vision or irritation.

For which side effects should a doctor be consulted immediately?

  • Chest pain
  • Sustained erection
  • Sudden decrease or even loss of vision
  • Allergic reaction

Heart attack risk is not increased

Since the PDE-5 inhibitor was launched on the market, there has been a lot of discussion about whether taking the drug increases the risk of myocardial infarction due to the small, but only temporary, lowering of blood pressure. In the meantime, however, many studies have shown that the heart attack rate is not higher. However, people with cardiovascular disease should note that there is a higher risk of a so-called cardiovascular event during and for two hours after sexual intercourse. Patients with controlled high blood pressure, stable angina pectoris, mild heart valve insufficiency, or previous myocardial infarction may take PDE-5 inhibitors. However, the situation is different for patients who have recently suffered from a heart attack or stroke,

Drug interactions

Side effects can also occur when taking other medications at the same time. The reason for this is that the effects of the preparations and PDE-5 inhibitors can add up or multiply. The interactions then result from this. These include, for example, nitrates, which are taken for angina pectoris (circulatory disorders in the coronary arteries), for alpha-blockers, which are used to lower blood pressure or to treat a benign enlarged prostate. In addition, side effects can also occur if metabolism is delayed by other active ingredients. 

This leads to a higher concentration in the blood and thus the effect is also increased. This can be done through drugs that are used to treat fungal diseases, HIV infections, or various antibiotics. PDE-5 inhibitors are very dangerous when they interact with vasodilators, as the effects are mutually amplified. If taken at the same time, blood pressure can drop, the heart rate can increase and further, serious consequences are possible.

Potency pills without a prescription on the Internet

In recent years, more and more young men have been complaining of erectile dysfunction. Very often the stressful work environment and an unhealthy diet are responsible for this. Since impotence often means emotional distress, the last resort is certainly to take the potency pill. For over 15 years, PDE-5 inhibitors have been one of the most effective means and methods for the treatment of impotence. Many men try to keep the disease a secret and don’t necessarily want to see a doctor. The Internet and online pharmacies have made it possible for a wide variety of sexual enhancers and pills to be available on the Internet without a prescription.

Order PDE-5 inhibitors online without a prescription

If you want to save yourself the trip to the doctor, you can order the potency pills over the Internet today. However, men should make sure that these are exclusively original products. If cheap counterfeits from China or the Far East are ingested, considerable damage to health can quickly be caused. PDE-5 inhibitors have been around since 1998 and the preparation has proven itself worldwide. In over 90% of the cases, the impotence of men can be fought very effectively.

How exactly do the preparations work?

Research has been carried out for a long time and the potency pills have been constantly improved in recent years. With the ingestion it is achieved that the blood flow is stimulated and as soon as an erection is present, the blood flow is slowed down. One advantage of the potency pill is that the effect lasts for a longer period of time and taking one pill a day is completely sufficient. Since an overdose can very often cause complications, the instructions of the manufacturer regarding the intake should be strictly adhered to.

PDE-5 inhibitors without a prescription from the internet

Ordering from an online pharmacy is relatively easy. The only requirement is usually that the customer has a credit card, otherwise payment cannot be made. Before the order is sent, the man very often has to fill out a questionnaire regarding the state of health. The information is checked by an expert or doctor and the PDE-5 inhibitors are only sent after the doctor has given the OK.

What is the disadvantage of ordering from the Internet?

Probably the biggest disadvantage is the personal advice. Although a lot of information can now be read in the various forums, an examination by a doctor can of course not be carried out. In addition, the preparations without a prescription can also be a little more expensive. However, many men are happy to accept these circumstances and orders over the Internet have been increasing for several months


Since many men feel very badly injured in their masculinity due to erectile dysfunction, the potency pills are often ordered over the Internet without a prescription. If it is ensured that the products are original, there is hardly anything that speaks against this order. Men should pay attention to the correct intake of the potency pills and should complaints (such as headaches or gastrointestinal problems) persist over a longer period of time, a doctor must be consulted in any case. Potency pills are very reliable and provide men with the necessary erection. In addition, more and more men report that taking potency pills also has a positive effect on stamina.

The duration of action of PDE-5 inhibitors

When men suffer from erectile problems, the only thing that helps very often is to use the potency pill. However, since there are already a large number of different preparations, it is very difficult to keep track of them. What is certain, however, is that PDE-5 inhibitors are certainly one of the most effective and promising agents. With the ingestion it is ensured that the erectile tissue in the male member is stimulated, the blood flow is promoted and the blood flow is slowed down. The result is that the man gets a long-lasting erection. Another advantage of the PDE-5 inhibitor is that the stamina up to the climax is positively promoted or influenced.

The duration of action for PDE-5 inhibitors

Probably the most important question for men is whether the preparation keeps what it promises and if so, how long the effect lasts. Although no guarantee can be given regarding the effect, the preparation has already helped numerous men to get an erection since 1998. In over 90% of men who suffer from impotence, PDE-5 inhibitors help very well. The duration of action is also very different and can last for several hours. Therefore, under no circumstances should you take more than one pill a day. Even after a man has climaxed, the potency pills with this ingredient ensure that a further erection is quite possible.

Sexual stimulation is necessary

So that something happens in the man’s pants, taking the potency pill is not over. In order for an erection to occur, the man must be sexually stimulated. Depending on the dosage, the pill should be taken with enough water around 30 to 60 minutes before the planned sexual intercourse. Whether or not a meal was previously consumed is irrelevant for the effect. The time of day is also not important.

Side effects of PDE-5 inhibitors

The ingredient has been tried and tested for many years, but unfortunately some side effects also have to be pointed out. Severe headaches, diarrhea or runny nose occur very often after ingestion. If these symptoms do not go away again in a timely manner, a doctor should be consulted in any case. If the instructions for intake are not observed, an overdose can have very serious consequences. A painful permanent erection is certainly the most harmless thing that can arise.

Another advantage is that, in addition to the excellent effect, the potency pills can also be ordered on the Internet or in online pharmacies without any prescription. The pills are often a little more expensive here, but many men appreciate the anonymity on the Internet and therefore like to spend more money on the effective pills.

PDE-5 inhibitors in foods

Which foods contain L-arginine? Are the values ​​sufficient as a substitute for PDE-5 inhibitors? High protein foods naturally contain L-arginine. These include, for example: Legumes, nuts as well as oil seeds and meat. Pumpkin seeds contain the highest proportion of L-arginine. The value is almost 4 times that of meat. In the seafood sector, prawns and seafood are another very essential source of L-arginine. L-arginine is only found in small amounts in milk and cheese. Basically, meat contains a lot of L-arginine. However, when it is prepared in the form of roasting, stewing, steaming or boiling, the high content of L-arginine in meat is greatly reduced. In order to achieve an increase in performance, experts recommend an intake of 1 to 2 grams per day.


  • Peanuts contain 3,400 milligrams per 100 grams
  • Pine nuts contain 2,400 milligrams per 100 grams
  • Walnuts contain 2,200 milligrams per 100 grams


  • Tuna contains 1,200 milligrams per 100 grams
  • Shrimp contain 1,700 milligrams per 100 grams


  • Chicken contains 1,400 milligrams per 100 grams
  • Lamb contains 1,400 milligrams per 100 grams

The daily requirement of L-arginine should be covered by a protein intake of around seventy to ninety grams a day. However, recording it alone proves to be a bit complicated. Apart from meat and fish, the other foods with a high L-arginine content are not part of our daily menu. It therefore seems more than sensible to take the amino acid in the form of a dietary supplement.

Why is L-arginine important

L-arginine is one of the proteinogenic amino acids, which are composed of different proteins. Arginine is a semi-essential amino acid in humans. This means that our body is very well able to produce on its own. But unfortunately not in sufficient quantities. L-arginine breaks down especially when there is great tension as well as physical and psychological stress or various illnesses. At this point at the latest, L-arginine must therefore be supplied to the body in another way, for example through the intake of food and suitable dietary supplements. Replacing PDE-5 inhibitors with dietary supplements will be difficult, however.

Because this substance not only plays a role in the treatment of ED (erectile dysfunction) but also in relation to other diseases, there should be no undersupply. Especially when treating ED, it is unlikely that food and dietary supplements alone will meet your needs. If the body receives sufficient L-arginine, it not only prevents diseases, but also improves athletic performance and increases male potency. The question of whether the effect of the PDE-5 inhibitor will be achieved remains open.

Buy PDE-5 inhibitors

For the treatment of erectile dysfunction, drugs with the active ingredient PDE-5 inhibitors, i.e. phsophodiesterase-5 inhibitors, are very often prescribed. This frequently used active ingredient is mainly found in the well-known drugs Slidenafil, Tadalafil, Avanafil and Vardenafil.

How do these drugs work?

A prerequisite for an erection in a man is the expansion of the blood vessels in the penis when it is sexually aroused. Only when the blood vessels in the penis fill can the penis straighten up. But one thing should be noted: PDE-5 inhibitors cannot increase sexual desire, the active ingredient only helps when sexual arousal is already present, i.e. only when sexual desire is present. PDE-5 inhibitors relax the tense muscles in the penis, allowing blood to flow into the erectile tissue and causing an erection.

PDE-5 inhibitors sold in Germany

In Germany there is the prescription PDE-5 inhibitor in the drugs, Sildenafil, Vardenafil, Tadalafil and Avanafil. Sildenafil was approved back in 1998, which is why there is most experience on this. Since 2004 the statutory health insurance companies have included PDE-5 inhibitors as “lifestyle drugs”. Health insurance companies therefore no longer cover the costs, even though the effectiveness of the treatment has been scientifically proven. The drugs are prescribed through a private prescription. The patient therefore has to pay for the PDE-5 inhibitor in full at the pharmacy.

The PDE-5 inhibitors differ

The active ingredient is decided from drug to drug, for example in the dose that has to be taken, in the time until the onset of full effect and in its so-called “half-life” with which the duration of action can be compared. Sildenafil must be taken about 30 to 60 minutes before sexual intercourse and then works for 3 to 5 hours. Vardenafil has to be taken 60 minutes before the desired effect and then works for 4 to 5 hours. Tadalafil works for about 17 hours and must be taken 120 minutes before sexual intercourse and Avanafil works for 5 hours and must be taken 30-45 minutes beforehand.

Properties of PDE-5 inhibitors

PDE-5 inhibitors have similar side effects regardless of the drug used. The most common include: headache, dizziness, flushing, indigestion (dyspepsia), swelling of the nasal mucosa, color vision disorders (not with Tadalafil and Avanafil) and back pain (especially with Tadalafil)

Interactions with other drugs

PDE-5 inhibitors must not be taken together with certain drugs, such as drugs for angina pectoris (coronary therapeutics, so-called nitrates and related preparations). In combination with PDE-5 inhibitors, these drugs also widen blood vessels, which can lead to a dangerous drop in blood pressure. If you are taking other medication, you must therefore always contact your doctor before taking PDE-5 inhibitors.


In some cases PDE-5 inhibitors should not be taken under any circumstances. This is the case with simultaneous administration of drugs that cause the release of NO (nitrogen monoxide), certain diseases such as severe cardiovascular diseases and unstable angina pectoris as well as severe heart failure. But also in patients with hepatic insufficiency, low blood pressure and recent strokes and heart attacks.

Buy on the Internet

When buying over the Internet, always make sure that you only buy from reputable sellers. Plagiarism can either not contain the full active ingredient or even contain life-threatening false active ingredients. Purchasing PDE-5 inhibitors from abroad can lead to health or even life-threatening damage.

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