Isotretinoin is used by doctors to reduce the production of sebum in the skin. At the same time, it has an anti-inflammatory effect and supports the faster renewal of the upper layer of the skin. The inhibition of inflammation is derived from the growth inhibition of the acne bacteria. With this approach, there is a chance that there will be fewer skin blemishes in the affected individuals.
Isotretinoin is available in different versions in the pharmacy. These include isotretinoin with 10 milligrams of the active ingredient and a pack size of 30 capsules, isotretinoin with 10 milligrams of the active ingredient and a pack size of 60 capsules, isotretinoin with 20 milligrams of the active ingredient and a pack size of 30 capsules, and isotretinoin with 20 milligrams and a pack size of 60 capsules. Ask your doctor about a prescription for isotretinoin.
What exactly is isotretinoin?
The capsules contain the active ingredient isotretinoin. On the one hand, the substance reduces the skin’s sebum production and, on the other hand, it has an anti-inflammatory effect and supports rapid skin renewal.
Isotretinoin is a highly effective drug that is only prescribed for severe cases of acne. Acne is the result of blocked sebum glands that later become inflamed. Why do people suffer from blocked sebum glands? This problem causes puberty excessively. Usually, pimples and pustules heal on their own. However, in some cases, blemishes can become serious. Cysts or abscesses can develop under the skin that is disfiguring and painful. Doctors use the term acne conglobata or acne cystica for this type of disease.
The active ingredient isotretinoin is one of the most important in its class in the treatment of acne. Isotretinoin was approved in the USA as early as 1982. You can use the active ingredient internally and externally.
Mode of action
The active ingredient is a retinoid. This means that the substance is a natural derivative of vitamin A. You may also know the substance under the name retinoic acid. Retinoids are naturally found everywhere in the body. With the help of the substance, accelerated growth is ensured in the cells.
In affected people who suffer from a severe form of acne, the pores quickly clog, which is caused by a high level of activity of the sebum glands. As a result, the sebum glands become inflamed, which means that the typical purulent pustules or pimples can be seen. The docking sites of the receptors are blocked during therapy with isotretinoin. This leads to increased cell growth within the top layer of the skin. As a result, the horny layer of the skin loosens and the skin layer peels easily. At the same time, the function of the sebum is impaired, which means that the pores are less clogged. In short, the skin cleanse itself from the inside out, refines the complexion and you can recognize this by fewer impurities.
Uptake / breakdown / excretion
Isotretinoin is absorbed orally and only around 25 percent is absorbed into the blood through the intestinal wall. With the help of the bloodstream, the substance moves to the liver, where it is broken down. The breakdown products are excreted in the urine and stool. If you do not take the active ingredient orally, but apply it to the skin, it will be absorbed very little into the blood. This means that the effect is almost local and you suffer from fewer side effects.
Oftentimes, acne is treated on the skin itself at the beginning. Anti-inflammatory lotions or creams can be used for this. Some doctors also use antibiotics. If the patient does not notice any improvement with this procedure, then there is the option of treating acne with isotretinoin.
How can you use isotretinoin?
In the package of the drug Isotretinoin, there are capsules containing active ingredients. Make sure you have enough liquid to take and swallow the capsule whole. Take isotretinoin with or shortly after a meal. Doctors prescribe isotretinoin as a regimen over several months (approximately four to six months). In severe cases, the treatment can be repeated after a two-month break.
Please note that taking isotretinoin makes the skin particularly sensitive to UV radiation. It is better to avoid sun contact or use a high sun protection factor outdoors, for example, 15 or higher.
Possible dosage of isotretinoin
A doctor will give you detailed instructions for your therapy. Please follow the instructions for taking. Please also read the package insert beforehand. If no other information is available, use the usual dosage. This is as follows:
Adult patients and children from the age of 12 take 0.5 milligrams per kilogram of body weight. If necessary, the daily dose can also be divided into two doses. You can swallow these doses throughout the day.
Please note that children under the age of 12 should not use isotretinoin. The drug is only intended to be taken after puberty. Isotretinoin should not be used in women who are pregnant or breastfeeding.
Possible side effects with taking isotretinoin
Many drugs may have side effects. However, the benefits are often greater than the side effects. Every organism reacts differently, which is why no general statements can be made about side effects. Ask your doctor if you have any doubts.
The following side effects can occur:
- Skin conditions such as flaky or dry skin or itching
- dry mucous membranes, such as a dry nose or dry eyes
- increased cholesterol
- Feeling weak
See the package insert for a complete overview of all side effects. Report any other side effects to your doctor. Contact a doctor immediately in the event of severe or life-threatening side effects.
When should I refrain from taking isotretinoin?
Isotretinoin is not suitable for all patients. External circumstances or other factors can lead the doctor to advise against the therapy. Please talk to your doctor before starting therapy with isotretinoin.
You shouldn’t take isotretinoin if:
- You are pregnant
- have liver disease
- You are hypersensitive to the active substance isotretinoin
- You are hypersensitive to any of the other ingredients
- have high levels of cholesterol / vitamin A or triglycerides in the blood
- You want to have children
Please talk to your doctor if you have any health problems. Inform him about hereditary diseases, previous illnesses, or other external circumstances. Please also remember to mention all medicines you are taking. Some drugs in combination with isotretinoin can interact.
Isotretinoin can lead to miscarriages, among other things. Taking isotretinoin during pregnancy can cause serious abnormalities in unborn children. Please keep this in mind when you start therapy. Be sure to take a pregnancy test before you start. Even if it has been a month since treatment, you should not become pregnant. Remember to use reliable contraception. If you still become pregnant during therapy, contact your doctor immediately.
You should also not use isotretinoin while breastfeeding. Read the warnings related to pregnancy.
Please note that taking isotretinoin may cause dizziness or blurred vision. If you are planning to actively participate in road traffic, please remember that there may be restrictions on your ability to react. Make sure you don’t suffer from any side effects.
Please keep in mind that alcohol increases the side effects of isotretinoin. Drink alcohol only moderately or not at all during therapy.
Is isotretinoin possible without a prescription?
No, a prescription is always required to use isotretinoin. This can be requested by consulting the online pharmacy.