How does CBD work in the body?


They say that CBD has many medical effects… It is sometimes described as a pure miracle cure!

The mode of action of cannabinoids has not yet been fully researched, however, scientific studies and field reports promise some potential pharmacological applications.

In order to understand how CBD works, we took a look at what actually happens when CBD is ingested into the body. We also looked at the different ways you take CBD and how they can have a decisive influence on when and how long it works.

The effect of CBD on nerve receptors

Cannabis consists of over 500 plant substances and these contain 85 cannabinoids. Cannabinoids belong to the group of phenol terpenes , they have not yet been discovered in any other plant in the world.

Cannabinoids can have very different pharmacological effects. The most well-known cannabinoids are THC, THCV, and CBD . However, other cannabinoids, such as CBG, CBC, CBN, or CBL, are also receiving increasing attention due to their potential medical utility.

Although hemp has been used as a medicine and as a food for centuries, medical research into cannabinoids is still in its early stages.

When the way THC works on the body was first studied in the 1940s, nerve receptors were discovered. THC combines with these substances to deploy its typical psychoactive effect. The most important receptors are CB1 and CB2.

CBD also corresponds with nerve receptors, however, it does not have a psychoactive effect.

The Endocannabinoid System (SEC)

To learn more about the effects of CBD in the body, one needs to take a closer look at what is known as the endocannabinoid system (ECS) . The ECS influences the nervous system by regulating many processes in the body. This is done through something called neurotransmitters (messengers), through which information is exchanged with nerve receptors.

The SEC controls the development and transmission of sensations such as fear, pain, love, joy or agitation.

How does CBD work?

The endocannabinoid system can be influenced by chemicals or plants like CBD. CBD attaches itself to receptors in the nervous system and can thus decisively regulate bodily processes.

CBD and receptors

The “communication” between the nerve cells thus takes place through the intermediary of messenger substances. If the body becomes imbalanced, messenger substances are released. In this case, CBD can have a regulatory effect on the exchange of information.

The process can be compared to an electrical circuit: the transmitter emits a messenger substance that the receiver receives. CBD can interrupt the “circuit” at the transmitter, at the receiver, or on the way. If, for example, the transmitter emits the pain signal, the pain can be relieved by blocking the receptor . CBD can have a regulatory effect on the following receptors:

  • CB1 receptor (cannabinoid receptor-1): these are located in the brain and intestine. They have an influence on pain, anxiety, stress, but also on learning processes and the musculoskeletal system.
  • CB2 receptor: CB2 receptors are located in bone cells and participate in the healing process of certain bone and nerve diseases.
  • Vanilloid receptors (types 1 and 2): CBD stimulates these receptors and may therefore contribute to an analgesic effect (Bisogno et al. 2001). In addition, the proliferation of brain tumor cells can be inhibited.
  • HT1A receptor: responsible for the acceptance of serotonin, also called the hormone of happiness. It influences depression but also learning abilities.

By docking with receptors, CBD can stimulate the natural healing process. It supports the natural balance (homeostasis) by its multiple mode of action.

How quickly and how quickly does CBD work in the body?

The duration and speed of action of CBD depends on the quality of the product, the type of consumption, the dosage and the physical conditions of the individual. The duration of the action can be between 4 and 8 hours .

The most popular way to take CBD is through something called sublingually, or under the tongue. To do this, CBD is applied, for example, in the form of oil under the tongue. So, CBD works in just a few minutes.

Even when smoking or evaporating, CBD enters directly into the bloodstream and works almost immediately.

You can also take CBD as a dietary supplement, for example in the form of tea , CBD candy, or capsules. The duration of the effect may vary if the medicine is taken on an empty or full stomach. It may take about 1 hour through the stomach for the effect to be felt. The advantage of this form of administration is that the effect can last longer, around 6 to 8 hours. This device is recommended for people who dislike the somewhat bitter taste of CBD oil under the tongue.

What’s the best way to take CBD?

CBD works best when it enters the bloodstream directly. This can be done intravenously or through the mucous membranes. In either case, the effect begins almost immediately or within a few minutes.

CBD oil

CBD oil is sold in small bottles, which are usually equipped with a pipette. So you can dose CBD oil more precisely.

In our experience, CBD oil has a better effect under the tongue. For this, the appropriate dosage is applied directly from the vial with the pipette under your tongue. If you have difficulty with this, you can also use a spoon, which should be placed under the tongue.

CBD oils are obtained from the extraction of CO2 and are sold as full spectrum oil or complete oil. Full spectrum CBD oil contains CBD as well as other cannabinoids, phenols, terpenes, vitamins and minerals.

CBD tea

The effect of CBD tea occurs later than when CBD is taken through the blood. The active ingredients still have to pass through the intestinal wall or the liver metabolism. Depending on the condition and dosage, the effect of CBD tea may take about an hour.

In our experience, the effect of CBD in tea form is comparable to that of other CBD food supplements such as CBD candy, capsules, or chocolate . However, experience has shown that CBD has a slightly longer effect when taken as a dietary supplement than when taken sublingually.

CBD liquid

CBD reacts almost immediately when you smoke it, it spreads directly into the bloodstream via the mucous membranes.

You can try a CBD liquid . If you vaporize CBD, the toxins are reduced compared to smoking.

How Does CBD Affect THC?

Unlike THC, CBD is neither psychoactive nor intoxicating. THC, on the other hand, achieves its intoxicating effect by docking with CB1 and CB2 receptors and transmitting its own substances. The mode of action of THC is similar to that of anandamide, the body’s messenger substance.

The interaction between CBD and THC has not yet been the subject of extensive scientific research. However, there is already scientific evidence for pharmacological interactions.

THC along with CBD has been shown to release the happiness hormone Serotonin. According to a study, a combination of THC and CBD may reduce memory impairment and may also suppress vomiting.

There are indications of possible positive interactions in other areas as well. For example, CBD could counteract the appetite stimulating effect of THC.

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