Drug Class and Mechanism of Action
Actos belongs to “thiazolidinediones” group of oral hypoglycemic, that are used in the treatment of type 2 diabetes mellitus. They act by reducing blood glucose or sugar. Actos acts blood glucose/sugar by reducing production of sugar in the liver and also by reducing release of sugar from liver. Actos also have action on blood lipids by decreasing triglycerides and increasing HDL cholesterol (which is good cholesterol and protect heart).
Therapeutic Uses of Actos
Actos is used in the treatment of type II diabetes mellitus. It is used with diet and exercise. Actos can be used alone or in combination with other oral hypoglycemic (one or more) or with insulin.
Direction of use of Actos
Actos should as directed by your doctor. There is also instruction in the leaflet that is provided with the pack. Actos is taken orally on full stomach or on empty stomach. As diabetes can not be cured Actos has to be taken lifelong so keep taking Actos after symptomatic improvement also. Actos should be taken at the same time everyday to help in remembering and also to get the best result.
Dose of Actos, if Missed
If dose of Actos is missed than it should be taken when remembered. Do not take 2 doses of Actos to catch up the missed dose. If dose is missed for long time that it is almost time for the next dose than skip the dose and continue the regular dosing schedule.
How to Store Actos
Actos should be stored at room temperature i.e. 59-86 degree Fahrenheit or 15-30 degree Centigrade. Keep it away from children and in a dry, tightly closed container.
More Information About Actos
Actos is a very toxic drug for children and it is important to keep it away from reach of children. If you have any doubt regarding Actos consult your doctor. If there is no improvement it may be due to inadequate dosing of medicine and you should consult your doctor. Do not share Actos with anybody.
Precautions to be Taken While Taking Actos
Avoid Actos if you have anything listed below:
- Allergy to any of the ingredients of Actos.
- In type 1 diabetes mellitus.
- If you have history of liver disease like jaundice (hepatitis) while taking similar medicine troglitazone.
- If you have heart failure (moderate to severe).
If you have any of the above do not hesitate to consult your doctor.
The following medical conditions can interact with Actos and you should inform your doctor or health care provider if you have any of the following:
- If you are pregnant, planning to have a baby or if you are breast feeding.
- If you have severe form of diabetes like diabetic ketoacidosis.
- If you have history of allergy to other medicines or any food.
- If you are taking some other medicine, herbal medicine, dietary supplements prescribed or non prescription medicine.
- If you have history of liver problems (jaundice, abnormal liver function test etc.), heart problems (heart failure), edema or swelling of body parts or eye problems.
Some medicines can interact with Actos and if you are taking any of the medicines listed below consult your doctor:
- Insulin, other oral hypoglycemic medicines (glipizide), gemfibrozil the chances of hypoglycemia (low blood sugar/glucose) are much higher.
- Rifampicin an anti tuberculosis medicine can reduce the effectiveness of Actos and cause hyperglycemia or high blood glucose/sugar.
- Actos can decrease the effectiveness of anticoagulation medicines like warfarin.
Possible Adverse Effects
- Common side effects of Actos are headache, muscle pain, weight gain and sore throat.
- Serious side effects (consult your doctor immediately) are allergic reaction to any of the ingredients (hives, skin rash, respiratory discomfort, tightness in chest, swelling of lips, tongue, mouth, sore throat), heart failure symptoms (edema of feet, ankle, hands, breathlessness), generalized weakness, liver problems (dark colored urine, jaundice of eye and skin, nausea, vomiting, stomach pain, loss of appetite), bone pain and hypoglycemia (anxiety, sweating, palpitation or increased heart rate, headache, dizziness, tremor, drowsiness and excessive hunger).